Tóth BI, Oláh A, Szöllősi AG et al."Sebocytes' makeup"-Novel mechanisms and concepts in the physiology of the human sebaceous glands. Eur J Physiol... Toth B I; Olah A; S2011osi A G;."Sebocytes' makeup": novel mechanisms and concepts in the physiology of the human sebaceous ...
The regulatory effects of sebocytes on melanocytes (HMel) are unknown. In this study, SZ95 sebocytes co-cultured with HMel, whether in direct cell contact or with SZ95 sebocytes in inserts, resulted in epidermal HMel flattening with increase in surface area and multiple small dendrites formation....
Reverse transcriptase-PCR analysis showed the expression of galectin-12, resistin, SREBP-1, and stearoyl-CoA desaturase mRNAs in SZ95 sebocytes. Immunoreactivity was observed for galectin-12 and SREBP-1 in the nuclei and resistin in the cytoplasm of basal sebocytes, and stearoyl CoA desaturase in...
The average cell proliferation daily value was significantly higher in the preputial sebocytes when compared to cutaneous sebocytes. These results demonstrated the existence of quantitative and qualitative differences in the mitotic activity of the preputial gland sebocytes in relation to the skin sebocytes...
Furthermore, NW-PM2.5 and W-PM2.5 significantly reduced sebaceous lipid synthesis and markedly promoted the production of inflammatory cytokines, including interleukin-1α (IL-1α), IL-6 and IL-8 in SZ95 sebocytes. Additionally, the expression of aryl hydrocarbon(Ah) receptor(AhR), AhR nuclear...
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IGF-1 induced a robust increase in phosphorylated p44/p42 protein in SEB-1 sebocytes after 24 hours (Figure 1a). Pretreatment of SEB-1 cells with 50μM of the MEK inhibitor PD98059 for 30 minutes prior to the addition of IGF-1 blocked activation of this pathway (Figure 1a), indicating...
To investigate the anti-inflammatory potential of EGCG, we evaluated pro-inflammatory cytokine synthesis in IGF-I-differentiated SZ95 sebocytes and found that expression of IL-1, IL-6, and IL-8 was decreased. These results provide early evidence that EGCG is an effective candidate for acne ...
When TFG was over-expressed using recombinant adenovirus, lipid production in sebocytes was increased along with an up-regulation of the expression of lipogenic regulators, such as PPAR-γ, SREBP-1 and SCD. Conversely, down-regulation of TFG using a microRNA (miR) decreased lipid production and...
Cosmetic and Investigational Dermatology James Nicoll Benjamin M Buehrer Zen-Bio, Inc., Research Triangle Park, NC, USA Introduction: Acne arises during puberty, in part, due to elevated hormones and growth factors which stimulate de novo lipogenesis (DNL) in primary sebocytes to significantly increa...