Hepatoportal sclerosis (obliterative portal venopathy) is a variant of chronic liver injury characterized by deposition of collagen in the periportal region with a loss of portal vein profiles and with or without diffuse fibrosis of the sinusoids (Mikkelsen et al., 1965; ...
7 Those treated with edaravone had a 33% reduction in the rate of progression of ALS Functional Rating Scale-Revised (ALSFRS-R) scores. The inclusion criteria were quite restrictive including a relatively homogenous population at a very early disease stage (within 3 years of onset, needing no ...
It is not yet known what the long-term outcome of patients who begin treatment at an early stage of their disease will be. There are two extremes in multiple sclerosis. The first is a "benign" syndrome in which patients have numerous lesions identified on MRI imaging, but have few -- ...
It is not yet known what the long-term outcome of patients who begin treatment at an early stage of their disease will be. There are two extremes in multiple sclerosis. The first is a "benign" syndrome in which patients have numerous lesions identified on MRI imaging, but have few -- ...
Classic intracranial manifestations of tuberous sclerosis include subependymal nodules and cortical/subcortical tubers.[4] The tubers are typically triangular in configuration, with the apex pointed towards the ventricles, and are thought to represent foci of abnormal neuronal migration. The T2 signal ab...
Genentech, a member of the Roche Group, announced results from the Phase IV CHIMES trial evaluating Ocrevus® in Black and Hispanic / Latinx people with relapsing multiple sclerosis. Black and Hispanic / Latinx peopl...
The pathologic hallmarks of MS lesions are (1) inflammation with T cells, B cells, and macrophages/microglia; (2) demyelination with oligodendrocyte loss during the chronic stage of the disease and varying degrees of remyelination; (3) axonal loss; and (4) gliosis with astrocyte proliferation...
Recent advances in sequencing technologies and collaborative efforts have led to substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS). This momentum has, in turn, fostered the development of putative molecular the
Tarhriz V, Eyvazi S, Musavi M et al (2019) Transient induction of Cdk9 in the early stage of differentiation is critical for myogenesis. J Cell Biochem 120. https://doi.org/10.1002/jcb.29204 Zhao Z, Zlokovic BV (2017) Remote control of BBB: a tale of exosomes and microRNA. Cell ...
Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the central nervous system (CNS). The underlying pathophysiology of MS is the destruction of myelin sheath by immune cells. The formation of myelin plaques, inflammati