首先是:图 a Heatmap of the area under the curve (AUC) scores of TF motifs estimated per cell by SCENIC. Shown are top five differentially activated motifs in iCAFs and mCAFs, respectively 也就是说,研究者定位到了两个细胞亚群 iCAFs and mCAFs,然后针对性的对这两个细胞亚群进行SCENIC分析,取...
单细胞进阶分析包括多个方面，如拟时序分析、细胞通讯分析以及SCENIC转录因子分析。SCENIC转录因子分析虽然在研究中变得更为常见，但其难度并未降低。理解SCENIC分析方法前，应通过实例学习并广泛阅读相关文献。例如，2018年CELL杂志上发表的文章《Toward Minimal Residual Disease-Directed Therapy in Melanoma》中...
首先是:图 a Heatmap of the area under the curve (AUC) scores of TF motifs estimated per cell by SCENIC. Shown are top five differentially activated motifs in iCAFs and mCAFs, respectively 也就是说,研究者定位到了两个细胞亚群 iCAFs and mCAFs,然后针对性的对这两个细胞亚群进行SCENIC分析,...
使用了SCENIC转录因子分析的结果制作了如下所示的3张图: (A) t-SNE shows cells colored by state identity(SCENIC approach). The identities are inferred bythe binary activities of the TF regulons. Cell identitiesinferred by SCENIC are largely overlappingwith the SCDE approach (B) SCENIC analysis pred...
首先是:图 a Heatmap of the area under the curve (AUC) scores of TF motifs estimated per cell by SCENIC. Shown are top five differentially activated motifs in iCAFs and mCAFs, respectively 也就是说,研究者定位到了两个细胞亚群 iCAFs and mCAFs,然后针对性的对这两个细胞亚群进行SCENIC分析,取...