A study details the molecular architecture of the double-membrane-spanning pore formed by the proteins nsp3 and nsp4 in double-membrane vesicles of SARS-CoV-2. Yixin Huang ,Tongyun Wang &Tao Ni News|18 July 2024 Long COVID lung damage linked to immune system response ...
The immune response to the spike protein of SARS-CoV-2 has been relatively well studied, but less is known about other viral proteins. Here, the authors identify immunopeptides from seven structural and non-structural SARS-CoV-2 proteins presented to the immune system by HLA molecules and conf...
病毒必须感染进入活细胞才能进行复制和传播。当SARS-CoV-2病毒找到合适的细胞时，它会注入一条包含整个基因组的RNA链。SARS-CoV-2病毒的基因组不到30000个碱基。研究学者已经鉴定出基因组能够转录多达29种蛋白质。对其他冠状病毒的研究为学者们提供了了解SARS-CoV-2蛋白的途径。但是一些蛋白质功能未知，有些蛋白质可能...
蛋白模型资料来源:Coronavirus by Maria Voigt, RCSB Protein Data Bank headquartered at Rutgers University–New Brunswick; Ribosome from Heena Khatter et al., Nature; Proteins from Yang Zhangʼs Research Group, University of Michigan. 原文链接 https://www.nytimes.com/interactive/2020/04/03/science...
大家好,本周为大家推荐一篇来自PNAS上的文章“Targeted in situ cross-linking massspectrometry and integrative modeling reveal the architectures of three proteinsfrom SARS-CoV-2“。文章的通讯作者是来自希伯来大学的Nir Kalisman教授、Dina...
SARS‑CoV‑2 do the spillover event in 2019 because it has genetic diversity. SARS-CoV-2 is composed by four subunits (spike, envelope, membrane and nucleocapsid proteins). Its RNA genome is encapsulated with nucleocapsid protein. The viral envelope is comprised of spike, envelope and ...
Coronavirus by Maria Voigt, RCSB Protein Data Bank headquartered at Rutgers University–New Brunswick; Ribosome from Heena Khatter et al., Nature; Proteins from Yang Zhangʼs Research Group, University of Michigan. 原文链接 https://www.nytimes.com/interactiv...
nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved...
8. Tripp RA, Haynes LM, Moore D, Anderson B, Tamin A, Harcourt BH, Jones LP, Yilla M, Babcock GJ, Greenough T, et al. Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteins. J Virol Met...
none of these proteins is a wise choice for the development of SARS-CoV-2 vaccines [25]. Therefore, the optimal target to elicit potent neutralizing antibodies, specific for SARS-CoV-2 is the S protein. Currently, the majority of protective countermeasures are S-based vaccines, and hence they...