SARS-CoV-2 主要通过S蛋白与宿主细胞表面的血管紧张素转换酶2(angiotensin-converting enzyme 2,ACE2)结合,并通过与跨膜蛋白酶丝氨酸酶2(transmembrane protease serines-2,TMPRSS2)的相互作用进入宿主细胞,随后释放出其遗传物质RNA并...
2020年4月3日，《纽约时报》著名专栏作家Carl Zimmer和《纽约时报》科学图形编辑Jonathan Corum发表了题为Bad News Wrapped in Protein: Inside the Coronavirus Genome 的文章。该文章将SARS-CoV-2编码的29种蛋白以模式图和简明易懂的文字呈现出来。该文作者之一Carl Zimmer是知名科普作家，在耶鲁大学教授科学与环境写...
SARS-CoV-2的29种蛋白质 16种蛋白质链·ORF1ab被SARS-CoV-2感染的细胞内部产生的第一个病毒蛋白实际上是16种蛋白质结合在一起的蛋白链(见上图)。其中的2两种蛋白像剪刀一样把蛋白从蛋白链上释放出来。 细胞破坏分子·NSP1这种蛋白质会减慢受感染细胞自身蛋白质的产生。这种破坏行为会迫使细胞产生更多的病毒蛋白。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus, with a single linear RNA segment, and a strain of coronavirus that causes COVID-19. Like other coronaviruses, SARS-CoV-2 has four structural proteins. The N (nucleocapsid) protein whic...
新冠病毒SARS-CoV-2的基因组主要编码29个蛋白,其中很多蛋白的结构信息都不明确,原因是这些蛋白在纯化过程中结构发生了不能逆转的变化,导致无法进行后续的分析。因此为了了解这些蛋白具体的结构和功能,需要开发一种在细胞内环境下提供结构信息的...
Learn more about SARS-CoV-2 infection cycle, immune responses, and potential therapeutics.References 1. Li F., 2016. Structure, function, and evolution of coronavirus spike proteins. Annu. Rev. Virol. 3:237-261. 2. Li F. et al., 2005. Structure of SARS coronavirus spike receptor-binding...
A study details the molecular architecture of the double-membrane-spanning pore formed by the proteins nsp3 and nsp4 in double-membrane vesicles of SARS-CoV-2. Yixin Huang ,Tongyun Wang &Tao Ni News|18 July 2024 Long COVID lung damage linked to immune system response ...
SARS-CoV-2 (or 2019-nCoV) is the causative agent for COVID-19. This virus belongs to lineage B of the β-coronavirus genus [1]. Coronaviruses are relatively large enveloped, positive-sense, single-stranded RNA (~30 kb) viruses. The SARS-CoV-2 genome encodes four structural proteins and...
2.非结构蛋白质（nsps）：SARS-CoV-2的基因组还编码了16个非结构蛋白质（nsp1至nsp16），这些蛋白质...
Three SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective In this study, the authors developed intranasal measles virus and mumps virus-based trivalent vaccines, each expressing three distinct SARS-CoV-2 stabilized prefusion spike proteins. They...