P151S N Omicron BA.4 and all sublineages Various countries Mutation associated with BA.4 sublineage WHO Variant of Concern Lineage Under Monitoring [10] P681H S Alpha B.1.1.207, B.1.1.7 Nigeria, United Kingdom Near highly variable S1/S2 furin cleavage site; Predicted to enhance ...
SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2doi:10.1186/s12879-022-07628-4Since the emergence of SARS-CoV-2, evolutionary pressure has driven large increases in the transmissibility of the ...
Due to the focus of vaccination on the SARS CoV-2 spike protein, spike has been associated with high levels of viral mutation and subsequent immune escape. Here the authors study a conserved epitope in SARS CoV-2 sub-domain-1 and characterise the neutralising antibody response and evasion in ...
SARS-CoV-2 belongs toSarbecovirusin the genusBetacoronavirusand has a 26 to 32 kb length positive single-stranded RNA genome encoding 9860 amino acids (aa). The SARS-CoV-2 genome contains two untranslated regions (UTRs); 265 nucleotides at 5′ end and 358 nucleotides at 3′ end, and 6 ...
India and South Africa. These three sublineages of Omicron share 21 alterations in the spike protein, wherein BA.2 contains 8 unique alterations and BA.1 contains 13 unique alterations (Fig.1b). Of course, BA.1+R346K has one alteration more than BA.1. Given these differences, their anti...
Three multiplex RT-qPCR assays developed for simultaneous discrimination of Omicron sub-lineages.A practical hierarchical detection workflow established for rapid and high-throughput variant monitoring.High assay specificity and sensitivity even in sewage samples containing mixtures of variantsAssays revealed the...
This CDC genomic variant surveillance tracks circulating Omicron sublineages in the U.S.; as of September 2024, most variants in the U.S. are KP.3, KP3.2.2, LB.1 and KP.2.3 Includes NOWCAST projection and modeling of what may happen in real-time since data lags by 2-3+...
After 12 times of serial passages in each cell lines, several consistent selected mutations were found on spike protein between the serially passaged SARS-CoV-2 in human cell lines and recent natural variants of SARS-CoV-2 like omicron. On the non-spike protein genes, selected mutations were ...
Omicron (lineage B.1.1.529) is the fifth variant to be named as a VOC by the World Health Organization (WHO) and was first detected in mid-November 2021 in Botswana, South Africa6 and in quarantined travellers in Hong Kong7. It has since split into three divergent sub-lineages (BA.1,...
the expected VEs vary between 11.9% for BA.1 and 33.3% for BA.2, using the mRNA vaccines. This might contribute to the considerable variations in VEs for Omicron reported from observational studies, whose cohorts might have been infected by divergent Omicron sublineages, in addition to differenc...