3. Faria NR., et al. Genomic characterisation of an emergent SARS-CoV-2 lineage in Manaus: preliminary findings.https://virological.org/t/genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-manaus-preliminary-findings/586 4. Xie X., et al. Neutralization of N501Y mutant SARS-CoV-...
Staying ahead of mutations may come down to a simple understanding of lineage, and which viral family they belong to.
However, as that wave receded in mid-January 2022, BA.2 became the dominant South African lineage. Despite being associated with a modest prolongation of the fourth wave, the displacement of BA.1 by BA.2 in South Africa was not associated with a substantial resurgence in cases, hospital ...
他们确定了几乎所有罕见的、广泛中和的抗HIV-1包膜蛋白gp120和gp41抗体的结构,以阐明可用于HIV-1疫苗设计的脆弱位点。他们已经在所有第1组流感亚型中定义了一个广泛中和的表位,并正在研究识别第2组以及跨所有亚型的其他抗体。 2. Background 2.1 关键突变位点对SARS-CoV-2功能的影响 1. 69-70del 该突变表现为...
Waning immunity and the emergence of the SARS-CoV-2 Omicron lineage led to reduced vaccine effectiveness and required vaccine updates. Here, the authors assess how different priming regimens affect the immunogenicity of BA.1 and BA.5 bivalent boosters. ...
Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses.Nat Microbiol. 2020 Feb 24. 3. Hoffman M, et al. The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into ...
5. GISAID.Clade and lineage nomenclature aids in genomic epidemiology studiesof active hCoV-19 viruses 2021 [cited 2021 JUN 22]. Available from:https://www.gisaid.org/references/statements-clarifications/clade-and-lineage-nomenclature-aids-in-genomic-epidemiology-of-active-hcov-19-viruses/. ...
2. Letko M, et al. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol. 2020 Feb 24. 3. Hoffman M, et al. The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMP...
1. Boni, MF., P. Lemey, X. Jiang, T. Tsan-Yuk Lam, B.W. Perry, T.A. Castoe, A. Rambaut, and D.L. Robertson. 2020. Evolutionary Origins of the SARS-CoV-2 Sarbecovirus Lineage Responsible for the COVID-19 Pandemic. Nature Microbiology 5 (11): 1408–17. ...
distributed macrophages in control human lung samples. Activated RIPK1 is known to mediate inflammation in the cells of myeloid lineage, including macrophages and neutrophils.14,31,32Thus, inflammatory cytokine storm in COVID-19 patients’ lung is associated with activation of RIPK1 in macrophages an...