Visualization of the nasal (mid-turbinate) and throat (pharyngeal) viral kinetics via swabs. Shown for each participant as measured (twice daily at 12 h intervals) via (b) RT-qPCR and (c) quantitative culture by focus forming assay (FFA), with values shown. The lower limit of ...
the number of viruses per lineage per week was normalized against the epidemiological curve derived from COVID-19 case counts and visualized using R. To further minimize biases only sequences categorized in the GISAID submission as obtained using a ‘baseline surveillance’ sampling strategy were incl...
Under the grant conditions of the Bill & Melinda Gates Foundation, a Creative Commons Attribution 4.0 Generic License has already been assigned to the Author Accepted Manuscript version that might arise from this submission. The findings and conclusions contained within this manuscript are those of ...
Sul state was posteriorly performed with GISAID data by retrieval of 4706 sequences included in the following parameters: (i) Location: South America/Brazil/Rio Grande do Sul, (ii) Collection date between March 1, 2020 and May 31, 2022, and (iii) Submission date up to September 30, 2022...
BMC Medicine (2023) 21:374 https://doi.org/10.1186/s12916-023-03070-8 BMC Medicine RESEARCH ARTICLE Open Access Assessing changes in incubation period, serial interval, and generation time of SARS‑CoV‑2 variants of concern: a systematic review and meta‑analysis Xiangyanyu...
We examined the sensitivity of our estimates to different assumptions regarding the average duration of infectiousness by repeating the analysis of the South Africa and Botswana dataset with different fixed values of the becoming non-infectious rate: 52.1 per year and 26.1 per year, which translate ...
Non-structural protein 15 (Nsp15) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) forms a homo hexamer and functions as an endoribonuclease. Here, we propose that Nsp15 activity may be inhibited by preventing its hexamerization through dr
Only 420 of these were collected between mid-February and early-April 2021, showing important delays between sample collection and sequencing or sample storage for long periods before sequencing and submission (e. g., waiting for reagents and/or research investments). Therefore, a significant amount...
Genomic surveillance identifies potential risk factors for SARS-CoV-2 transmission at a mid-sized university in a small rural town Article Open access 16 May 2023 Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning Article Open access ...
UTLA-level 2020-mid-year population size estimates were downloaded fromhttps://www.ons.gov.uk/peoplepopulationandcommunity/populationandmigration/populationestimates/datasets/populationestimatesforukenglandandwalesscotlandandnorthernireland. Population size data were used to calculate the proportion of the popul...