although there were significant increases in sars-cov-2 seroprevalence in children during the latest waves of the pandemic, mainly due to the spread of the delta variant,∼50–70% of children globally likely remained sus...
We cannot exclude the possibility that all detected introductions are due to direct human contact, although it seems unlikely. Indirect environmental transmission through wastewater and stormwater37,38 is possible, but the virus has never been successfully isolated from wastewater, let alone run-off. ...
Data from two large networks of community-based laboratories in France were collected during standard of care in the 2023-2024 epidemic season (n = 511,083 RT-PCR tests). Multiplex PCR diagnostic tests were used. Patients’ demographics and symptoms were reported in addition to viral sequenc...
Article Open access 27 May 2024 Main The post-acute sequelae of SARS-CoV-2 infection—also referred to as Long COVID—have been characterized1. Increasingly, vaccinated individuals are being diagnosed with COVID-19 as a result of breakthrough SARS-CoV-2 infection (BTI)2,3. Whether people wi...
Specimens that failed molecular testing due to contamination or that were misidentified or had a cycle threshold value in the inconclusive range were considered negative. Whole-genome sequencing was attempted on all SARS-CoV-2 infection–positive specimens with an adequate viral quantity in the ...
The opposite limitk → 0 corresponds to a distribution for new infections with extremely heavy tails, i.e., one where super-spreading is dominant. In this case, the drift in Eq. (5), which quantifies expected frequency changes due to selection, is unchanged. However, the diffusion ma...
. Recombinant haplotypes were not detected in the other participants, potentially due to limited sensitivity of recombination analysis in the setting of low intra-host genetic diversity. Nevertheless, we conclude that infections with multiple SARS-CoV-2 founder sequences can be detected in PWH, and ...
A varying wastewater composition, e.g. due to irregular industrial influences or heavy rainfall events, can lead to changing concentrations of the pathogens. To take these external influences into account, the measured viral load can be normalized. In AMELAG, normalization of the SARS-CoV-2 data...
Finally, as stated in the study itself that the abnormal neurodevelopmental outcome could be caused by psycho-social stress induced by the pandemic due to job-housing loss and food insecurity (3), hence it becomes rather imperative to study the impact of these stressors along with social ...
These data could be biased due to targeted sequencing of SGTF samples and stochastic effects (such as superspreading) in a low-incidence setting, which can lead to overestimates of the growth advantage and, consequently, of the increased transmissibility and immune evasion. Second, without reliable...