After 150,000 articles and 17 million genome sequences, what has science taught us about SARS-CoV-2? Ewen Callaway Book Review|24 February 2025 The racial injustice laid bare by COVID must not be forgotten A methodical analysis of pandemic policies in Chicago, Illinois, reveals why short-ter...
S. Novel vaccine technologies: essential components of an adequate response to emerging viral diseases. J. Am. Med. Assoc. 319, 1431–1432 (2018). Article Google Scholar Bettini, E. & Locci, M. SARS-CoV-2 mRNA vaccines: immunological mechanism and beyond. Vaccines 9, 147 (2021). ...
SARS-CoV-2 mRNA vaccines induce robust anti-spike (S) antibody and CD4+ T cell responses. It is not yet clear whether vaccine-induced follicular helper CD4+ T (TFH) cell responses contribute to this outstanding immunogenicity. Using fine-needle aspiration of draining axillary lymph nodes from ...
Can help with optimizing the sequence of the mRNA vaccine candidate to maximize protein expression. Can be used to sequence and characterize the neutralizing antibodies generated as a response to the virus which could potentially have therapeutic or prophylactic utility. The entire workflow...
A single dose of an mRNA vaccine might quickly and robustly boost a previously primed immune response following natural disease.Vaccination is the most important strategy to end the pandemic. However, emergence of multiple SARS-CoV-2 variants with reduced susceptibility to disease- and vaccine-...
SARS-CoV-2表面含有刺状糖蛋白,这是当前疫苗开发的主要目标,因为针对这种蛋白的抗体可以中和感染。公司和学术机构已开发出基于S糖蛋白及其抗原域和表位的疫苗,这些抗原域和表位已被证明能有效产生中和抗体。然而,新的SARS-CoV-2变种的出...
Can help with optimizing the sequence of the mRNA vaccine candidate to maximize protein expression. Can be used to sequence and characterize the neutralizing antibodies generated as a response to the virus which could potentially have therapeutic or prophylactic utility. The entire work...
We therefore review current knowledge relevant to humoral and cellular immunity to SARS-CoV-2 in humans and its application to vaccine development. Download: Download high-res image (1MB) Download: Download full-size image Figure 2. SARS-CoV-2 infection and the development of immunity The ...
The public health crisis caused by SARS-CoV-2 highlights the importance of rapidly developing effective and safe vaccine candidates against these viruses. SOLUTION: The present disclosure relates to coronavirus ribonucleic acid (RNA) vaccines, as well as methods of using and compositions comprising the...
SARS-CoV-2 evolution poses a risk to vaccine and antiviral drug efficacy. Here, Gagne et al. report the development of a variant-agnostic protein, RBD-62, with enhanced ACE2 binding obtained through in vitro evolution and show that RBD-62 inhalation protects nonhuman primates against SARS-CoV...