This book chapter presents a concise overview of SARS-CoV-2, the virus responsible for the COVID-19 pandemic. It explores viral classification based on morphology and nucleic acid composition with a focus on DNA and RNA viruses , the SARS-CoV-2 structure including the structural as well as ...
SARS-CoV-2 COVID-19 Drug development Antibody Inhibitors 1. Introduction The life cycle of SARS-CoV-2 begins with the binding of the receptor-binding domain (RBD) in the S1 subunit of spike protein to angiotensin converting enzyme 2 (ACE2) which is expressed on the surface of epithelial ce...
The replication cycle of SARS-CoV-2 explained based on current literature. We provide a graphical representation of the SARS-CoV-2 Life Cycle with its St...
The life cycle of SARS-CoV-2. The life cycle of SARS-CoV-2 includes the following stages: receptor recognition via S protein; viral entry through the endocytosis pathway or the membrane fusion pathway; replicative transcription complex formation; viral RNA replication in DMVs; virion assembly in ...
SARS-CoV-2 life cycle in the host cell. The spike proteins of the virus bind to cellular receptors i.e., Angiotensin-converting enzyme 2 (ACE2). Upon entry via endosomal pathways, the viral RNA is released in the cytoplasm. Polyproteins are produced by the translation of ORF1a and ORF1...
Therefore, a detailed understanding of the molecular events and the underlying mechanisms in the life cycle of SARS-CoV-2, including the viral replication and assembly, is urgently needed. SARS-CoV-2 is an enveloped, positive-sense RNA virus containing a non-segmented single-stranded RNA genome ...
This information can help provide detailed insights into virus structure and function, which might inform drug and vaccine programs designed to prevent infection and disease. Learn more about tools for vaccine research › New SARS-CoV-2 Serology Assays: Rapidly detect antibodies (immuno...
Mechanism of action of tannins in inhibition of SARS-COV. The life cycle of SARS-CoV-2 in the host cell. 1; gRNA, genomic RNA 2; RdRP, RNA-dependent RNA polymerase Full size image Derivatives of tannins Nineteen LigX tannins have been revealed by an interactive affinity study. To implemen...
Fig. 2. The SARS-CoV-2 viral life cycle and potential sites for drug-action. 1.1. SARS-CoV-2 3CLpro The SARS-CoV-2 3CLpro is a 306-amino acid, 33.8 kDa, a hydrophilic proteolytic enzyme belonging to the PA class of proteases. Its sequence identity is conserved with those of SARS-...
The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the dynamics of early cellular responses to this disease remains limited1. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics profiling of nasop