Spike 单体由一个 N 端 S1 亚基组成,该亚基介导受体结合,以及一个靠近膜的 S2 亚基,该亚基介导膜融合。 SARS-CoV-2 和 SARS-CoV-1 的序列同源性约为 79%,并且两者都使用血管紧张素转换酶 2 (ACE2) 作为其细胞受体。 针对SARS-CoV-1 Spike 的抗体反应非常复杂。 在一些快速产生高效中和抗体反应的患者中...
SARS-CoV-2 RNA-依赖的RNA聚合酶 (RdRp)活性存在于nsp12,它以引物依赖性的方式催化三磷酸核苷 (NTPs)之间形成磷酸二酯键。在与nsp7和nsp8形成复合物后,nsp12获得持续性合成大RNAs的能力。此外,nsp8也显示出引物酶活性,即合成RNA引物的能力,从而使病毒可以从头合成RNA。冠状病毒家族RdRp是高度保守的,SARS-CoV-...
An oral SARS-CoV-2 M(pro) inhibitor clinical candidate for the treatment of COVID-19. Science 374, 1586-1593 (2021).[6] H. Mukae et al., Efficacy and Safety of Ensitrelvir in Patients With Mild-to-Moderate Coronavirus Disease 2019: The Phase 2b Part ...
基于这一特性,更多的研究证明了GO-single PCR在疾病诊断中的优异检测性能。 研究提出了一种高灵敏度的 GO-多重 qPCR 方法,用于同时检测两个 SARS-CoV-2 基因(RdRP 和 E)和一个参考基因 (RNase P)。在GO多重qPCR系统中,GO在进入扩增系统之前预吸收每个正向引物以形成特定的GO正向引物复合物。靶基因扩...
[12] S. Gandhi et al., De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report.Nat. Commun.13, 1547 (2022). [13] N. S. Zuckerman...
SARS-CoV-2RdRpmolecular dockingmolecular dynamics simulationdrug repurposingNew treatment against SARS-CoV-2 now is a must. Nowadays, the world encounters a huge health crisis by the COVID-19 viral infection. Nucleotide inhibitors gave a lot of promising results in terms of its efficacy against ...
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The structure of NSP12 in SARS-CoV-2 contains a C-terminal RdRp domain (amino acid residues S367 to F920), which carries the RNA polymerase catalytic activity common to all RNA viruses and an N-terminal nidovirus RdRp-associated nucleotidyltransferase (NiRAN) extension (amino acid residues D6...
SARS-CoV-2 has spread rapidly around the world, with Brazil currently considered an epicenter of the pandemic. The Northern region has the second highest incidence coefficient, as well as the third highest mortality rate in the country. This st
The results show the effectiveness of Sofosbuvir, Ribavirin, Galidesivir, Remdesivir, Favipiravir, Cefuroxime, Tenofovir, and Hydroxychloroquine, in binding to SARS-CoV-2 RdRp. Additionally, Setrobuvir, YAK, and IDX-184, show better results, while four novel IDX-184 derivatives show promising ...