regression models associating maternal SARS-CoV-2 status with the neurodevelopmental outcome, then added maternal age in years, race and ethnicity, insurance type (public vs private), as well as offspring sex and preterm status, to yield unadjusted and adjusted estimates of effect and 95% CIs. ...
Download: Download full-size image Fig. 2. The genome of SARS-CoV-2 contains over 29,000 bases and codes for 29 proteins. SARS-CoV-2 has four structural proteins: The proteins E and M that form the viral envelope, protein N binds to the RNA genome of SARS-CoV-2 and S protein, whi...
As a result, there is increased expression of immune-responsive gene-1 (IRG1) that produces itaconate from cis-aconitate in the mitochondria and disrupts the TCA cycle activity [140] (Fig. 6). Itaconate inhibits succinate dehydrogenase (SDH) that oxidizes and converts succinate to fumarate and...
Results of this meta-analysis were presented as pooled risk ratios (RRs) with 95% CIs. We also performed meta-analyses to pool case fatality rates by tumor type and by type of cancer treatment among patients with cancer. Results of these meta-analyses were presented as pooled proportions ...
The cis- and trans-cleavage was confirmed using agarose gel electrophoresis. As shown in Fig.2b, the band of intact dsDNA template was observed (indicates as “T”). After the CRISPR reaction with the right crRNA, the band of the template disappeared (cis-cleavage), and fluorescence of the...
VV116 (JT001) is an oral drug candidate of nucleoside analog against SARS-CoV-2. The purpose of the three phase I studies was to evaluate the safety, tolerability, and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy subje
the single-stranded RNA genome could fold back onto itself to form the so-called cis-acting elements in the 5′- and 3′-untranslated regions (UTR)5,10,11,12. Previous studies5,11,12have demonstrated that those cis-acting elements are essential for viral transcription and replication through...
, and co-morbidities, was estimated by generalized linear models. The level of significance for this set of analyses was set at a 2-tailedp < 0.05, with 95% CIs. All statistical analyses were performed with the use of STATA 16 MP (Stata Corp., College Station, TX)....
and viral vectors. As used herein, a “vector” may refer to a recombinant nucleic acid that has been engineered to express a heterologous polypeptide (e.g., the fusion proteins disclosed herein). The recombinant nucleic acid typically includes cis-acting elements for expression of the heterologou...
In general, expression vectors of utility in recombinant DNA techniques are often in the form of “plasmids” which refer generally to circular double stranded DNA loops, which, in their vector form are not bound to the chromosome. In the present specification, “plasmid” and “vector” are u...