Sarcomas are a heterogeneous group of neoplasms derived from tissues of the mesenchyme such as bone, cartilage, muscle, and other connective tissues. Their heterogeneity is highlighted by the identification of over 100 different sarcoma subtypes which vary in pathology, clinical presentation, molecular c...
In this review, we discuss the most recent studies tackling the involvement of the immune system; a key player in the emergence of the different types of spine sarcomas and the promising immune-mediated targeted therapy that can be applied in these kind of rare cancers....
includes specific sections relating to the management of sarcomas at defined anatomical sites: gynaecological sarcomas, retroperitoneal sarcomas, breast sarcomas, and skin sarcomas. These are generally managed collaboratively by site specific multidisciplinary teams linked to the regional...
Soft tissue sarcomas (STS) are heterogeneous rare malignancies accounting for less than 1% of all cancers [1]. They include more than 70 histological and molecular subtypes with varying biology, molecular aberrations, and variable response to treatment [2]. Generally, surgery with or without radiati...
osteosarcomas and 5% as gastrointestinal mesenchymal tumors. In terms of prevalence, they account for less than 1% of adult cancers, but one fifth of solid malignancies in children [5]. However, the prevalence of SARC may be underestimated because SARC that develop in parenchymal organs are ...
Jonathan C. Trent, MD, PhD:Yes, Bill, that’s a great idea. Sarcoma is a collection of different cancers. In fact, if one were to look in the pathology textbooks, there are over 200 different types of soft tissue sarcomas. Each one of those is a different type of cancer. They’re...
To improve the outcomes of children with bone sarcomas, a better understanding of the biology of these cancers is needed, together with informed use of targeted therapies that exploit the unique biology of each disease. Here we summarize the current state of knowledge regarding the contribution of...
Sarcomas are malignant mesenchymal tumors that account for approximately 1% of adult solid cancers [1]. Sarcomas can be divided into more than 50 distinct histological subtypes, and many of these subtypes are not limited to a specific location of the body [2]. Due to its rarity and morphologic...
Cancer stem-like cells (CSCs) in sarcomas and other cancers may be a source of therapy resistance as well as distant metastasis4,5. CSCs share characteristics with normal adult stem cells, specifically the capacity for self-renewal and pluripotent differentiation6. Methods to identify CSCs include...
are involved in the control of transcription and gene expression, wherein unmethylated CpG islands allow transcription, whilst hypermethylated promoter regions repress gene expression1,2,3,4. Methylation alterations have been implicated in transformation of mesenchymal stem cells during sarcomagenesis5,6. ...