发现S100a4双阴性的T细胞IFN-γ水平更高。流式细胞术分析显示,与S100a4双阴性CD4 T细胞共培养的标记T细胞的增殖显著高于对照组的CD4 T细胞。这些都表明S100a4以细胞自主的方式在胶质瘤相关免疫细胞中发挥作用,以抑制免疫反应并促进胶质瘤生长。 0...
此外,它还可用于确定大多数样本中通常被激活的分子靶点的优先顺序,根据特定细胞类型的表达模式预测靶上和靶外效应,并分析特定的细胞:细胞相互作用和表达模式,以设计有效的联合疗法。 reference:Single-cell analysis of human glioma and immune ...
钙离子结合蛋白S1OOA4在肿瘤中表达及其临床应用进展胡剑浩吴建胜肿瘤的侵袭与转移是一个非常复杂的过程,涉及细胞黏附和分离、细胞外基质重建、细胞运动、血管生成等生命过程。许多基因及其表达产物都参与其中.最近对钙离子结合蛋白S100A4作用机制的研究结果表明,S100A4可促进肿瘤转移,对人类癌症发生和发展的预测具有一定的参...
T Cabezón, JE Celis, I Skibshoj, J Klingelhofer, M Grigorian, P Gromov, F Rank, JH Myklebust, GM Maelandsmo, E Lukanidin, N Ambartsumian Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer Int J Cancer, 121 (2007), pp. ...
与正常组比较,正常-病毒对照组、基因治疗组小鼠视网膜S100A4蛋白表达明显下调,差异有统计学意义(t=4.12、3.42,P<0.05)。与单纯模型组、空白载体组比较,基因治疗组小鼠视网膜S100A4(t=5.85、6.13)、bcl-2(t=3.63、3.36)、CREB(t=2.96、3.40)蛋白表达明显下调,差异均有统计学意义(P<0.05);Caspase-3蛋白表达明显...
A calcium binding protein, S100A4, me- diates T cell dependent cytotoxicity as a transformation-associated antigen. Microbiol Immunol 49, 49-56.Kondo N. A calcium binding protein, S100A4, mediates T cell dependent cytotoxicity as a transformation-associated antigen. Microbiol Immunol. 2005; 49 :...
Tumour cell invasion and metastasis are the hallmark of malignant neoplasm. S100A4 is a member of small calcium-binding protein family and is involved in the cell proliferation and cancer progression. S100A4 is capable of inducing metastasis in animal models and is associated with aggressive phenotyp...
7. Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S. et al. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020;27:147-157.e147 8. Saboor F, Reckmann AN, Tomczyk CU, Peters DM, Weissmann...
The cells were harvested at 8000 rpm for 10 min, and the cell pellets were resuspended in lysis buffer (50 mM Tris pH 7.5, 10% glycerol, 300 mM KCl, 5 mM DTT, 1 mM EDTA, 1 mM PMSF and 5 μg/ml each of chymostatin, leupeptin, and pepstatin). The cell lysates were frozen at ...
近日,贵州医科大学附属医院临床检验中心余芳教授团队在Frontiers inImmunology期刊上发表了题为“S100A4 iscritical for a mouse model of allergic asthma by impacting mast cell activation”的文章,揭示了钙结合蛋白成员S100A4蛋白通过调控肥...