The article focuses on a study which performs a population pharmacokinetic-pharmacodynamic analysis of the S(+)-ketamine analgesic and nonanalgesic effects. In this study, ten men and women are administered with ketamine infusion and the infusion is increased per 15 minute. It discovers that ...
Effects of Ketamine, S-Ketamine and MK 801 on Integrin Beta-3-mediated Cell Migration in Pancreatic Carcinoma Introduction: Pancreatic ductal adenocarcinoma is one of the most aggressive malignancies in humans. The main reason for its unfavourable prognosis is the ... M Malsy,V Hofer,SM Schmidbau...
P-3-7 Differential effects of S-ketamine and R-ketamine on psychopathology and brain energy metabolism measured by FDG-PET in humansP-3-7 Differential effects of S-ketamine and R-ketamine on psychopathology and brain energy metabolism measured by FDG-PET in humansThe ketamine/PCP-model of psych...
The N-methyl- d-aspartate (NMDA) receptor antagonist ketamine has rapid and potent antidepressant effects in treatment-resistant major depressive disorder ... Niciu,J Mark,Henter,... - 《Annual Review of Pharmacology & Toxicology》 被引量: 115发表: 2014年 Oral ketamine for the rapid treatment...
The effects of the psychotomimetic S-enantiomer of the anaesthetic ketamine in two different subanaesthetic doses were compared with those of a placebo. In spite of dose dependence and grave subjective and significant objective psychopathology, no significant impairment of binocular depth perception was...
Differently valenced ketamine-induced ASCs mediated opposing effects on right anterior insula activity. Participants experiencing relatively higher depersonalization induced by 0.5 mg/kg of ketamine showed relief from negative brain states (reduced task-evoked right anterior insula activity, 0.39 SD...
Ketamine—an anesthetic also known for its illicit use as a recreational drug—has undergone a thorough reputational rehabilitation in recent years as the medical establishment has begun to recognize its wide-ranging therapeutic effects. The drug is increasingly used for a range of medical purposes, ...
Method: Functional MRI...doi:10.1016/j.biopsych.2017.02.276Reed, JessicaNugent, AllisonFurey, MauraSzczepanik, JoannaEvans, JenniferZarate, CarlosBiological Psychiatry
Ketamine's effects on mood are more commonly accepted, but the impact on sleep is often overlooked. The benefits to both may be because the neuroplasticity of the brain is enhanced. Source: Valenty/Shutterstock Ketamine’s impact on sleep has been generally overlooked. ...
Ketamine's effects on mood are more commonly accepted, but the impact on sleep is often overlooked. The benefits to both may be because the neuroplasticity of the brain is enhanced. Deep sleep, in particular, is increased, seemingly without a loss of other types of sleep. Source: Valent...