S-allycysteineVarious components of garlic and aged garlic extract, including allicin, S-allylcysteine (SAC) and volatile metabolites of allicin were determined in breath, plasma and simulated gastric fluids by HPLC, gas chromatography (GC) or HPLC- and GC-mass spectrometry (MS). Data indicate ...
CYSTEINEDIETARY supplementsWATER samplingIntroduction: In this study, a new high performance liquid chromatographic method was developed to determine the amount of allicin (AL) and s-allyl cysteine (SAC) in Allium sativum L. extracts. Methods: In the method, C18 ...
Allicin induces thiol stress in bacteria through S-allylmercapto modification of protein cysteines. J. Biol. Chem. 2016, 291, 11477-11490. [CrossRef] [PubMed]Muller, A.; Eller, J.; Albrecht, F.; Prochnow, P.; Kuhlmann, K.; Bandow, J.E.; Slusarenko, A.J.; Leichert, L.I.O...
(Nrf2) activator and cysteine supplier, previously shown to have anti-oxidation protective effects in cultured cells and animal models. Here, we studied the therapeutic potential of ASSNAC with and without Alendronate in ovariectomized (OVX) female mice. The experimental outcome included (i) femur ...
nutrients Article S-Allylmercaptocysteine Attenuates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation Xiaosong Zhu 1, Xiaoyan Jiang 1, Ang Li 1, Zhongxi Zhao 1,2,* and Siying Li 1,* 1 School of Pharmaceutical Sciences, Shandong University, 44 ...
antioxidants Article Sulfuric Odor Precursor S-Allyl-l-Cysteine Sulfoxide in Garlic Induces Detoxifying Enzymes and Prevents Hepatic Injury Yusuke Yamaguchi 1 , Ryosuke Honma 1, Tomoaki Yazaki 1, Takeshi Shibuya 1, Tomoya Sakaguchi 1, Harumi Uto-Kondo 2 and Hitomi Kumagai 1,* 1 Department of ...
S-Allylmercapto-N-acetylcysteine (ASSNAC) is a conjugate of NAC with the active residue of allicin, S-allylmercaptan, rendering the molecule a hydrophobic nature that improves its cell and tissue permeability. We have shown in vascular endothelial cells that ASSNAC interacts with free cysteine ...
The Yap1 transcription factor coordinates the oxidative stress response in yeast, and ∆yap1 yeast cells were more sensitive to CSA than the wildtype, indicating that as for allicin, CSA caused oxidative stress in the cells. It was previously shown that allicin directly targets specific cysteine...
Allicin Induces Thiol Stress in Bacteria through S-Allylmercapto Modification of Protein Cysteines. J. Biol. Chem. 2016, 291, 11477–11490. [CrossRef] [PubMed] 16. Gruhlke, M.C.H.; Schlembach, I.; Leontiev, R.; Uebachs, A.; Gollwitzer, P.; Weiss, A.; Delaunay, A.; Toledano...