氟尿嘧啶(5-FU)+顺铂(CDDP)的CCRT广泛用于不能手术的局部晚期食管癌,但老年人因药物毒性难以完成治疗,治疗与单纯放疗相比,尚不明确疗效哪种治疗方式更加有效。 S-1是一种口服的5-FU衍生物,YonglingJi等人此前曾在老年食管癌患者中进行过I/II期研究,S-1+RT毒性轻微,2年OS达到了45.1% 的主要终点。 本次报道的...
RESULTS: The CPT+S-1 group showed a higher response rate than the CDDP+S-1 group (57.1% [95% CI 31.2-83.1%] vs. 42.9% [95% CI 16.9-68.8%]; p < 0.44). The median survival time of the CPT-11+S-1 group was significantly longer than the CDDP+S-1 group (16.1 months [95% ...
Blood–labyrinth barrier (BLB) damage has been recognized as a key mechanism underlying cisplatin (CDDP)-induced hearing loss. Inflammation within the cochlea, triggered by CDDP, is a key pathological response. However, the relationship between CDDP-induced inflammation and BLB dysfunction remains elusi...
Y2细胞,小鼠成纤维细胞 人顺铂耐药株,COC1/CDDP细胞 人食道上皮细胞裂解物HEEpiCL鸦胆子苦醇(标准品)质量规格:HPLC>98%,标准品(+)-Brusatol 非洲绿猴肾细胞;CV-1盐酸哌唑嗪(标准品)质量规格:含量测定Prazosin HCl IGFBP3 Others Human 人 IGFBP3 / IBP3 人细胞裂解液 (阳性对照) 7-羟基质量规格:≥97...
we performed RNA-immunoprecipitation and RT-PCR experiments with Flag antibody in ZBP1-reconstituted MDFs. As shown in Fig.5dand Supplementary Fig.5b, we found RLTR1B-int and RLTR45-int were markedly increased in Flag-ZBP1 precipitated samples upon ETO or CDDP-treatment, respectively. Together,...
Methods: 30 patients with resectable, locally advanced esophageal cancer (cT3,Nx,M0) underwent neoadjuvant radiochemotherapy (CDDP, 5-FU, 36Gy). All tumors were resected by transthoracic en bloc esophagectomy and objective histomorphologic regression was defined: Grade I: minor response/no change (...
3176..671134±± 037.10630 14 cisplatNin (CNDDP) rCelferenceH[73] O 105.7.837±± 01.3743 215.9.965±± 100.5.945 107.9.105±± 01.1596 209.2.145±± 07.0664 316.6.114±± 07.1060 cisplatin (CDDP) reference [73] 0.73 ± 0.34 1.96 ± 0.54 0.90 ± 0.19 0.24 ± 0.06 1.61 ± 0.16 ...