S-Methyl-5′-thioadenosine phosphorylaseEC number 2.4.2.28 Systematic name S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-α-d-ribosyl-transferase RecommenSpringer Berlin Heidelbergdoi:10.1007/978-3-540-49753-0_28
目前,已发现了11种PRMT家族的成员,主要的研究热点集中在PEMT5上。 MTAP(methylthioadenosine phosphorylase,甲硫腺苷磷酸化酶)常与体内常见的抑癌基因CDKN2A发生共缺失现象,这种共缺失现象在肿瘤中的比例可达9%~15%。 PRMT5和MTAP是合成致死组合 2016年的两篇背靠背《Science》...
目前，已发现了11种PRMT家族的成员，主要的研究热点集中在PEMT5上。MTAP（methylthioadenosine phosphorylase，甲硫腺苷磷酸化酶）常与体内常见的抑癌基因CDKN2A发生共缺失现象，这种共缺失现象在肿瘤中的比例可达9%~15%。PRMT5和MTAP是合成致死组合 2016年的两篇背靠背《Science》文章首次报道了抑制PRMT5在MTAP缺失肿...
CRISPR)基因编辑技术使基于“合成致死”的药物研究开启新的篇章;蛋白质精氨酸甲基 转移酶 5(protein arginase methyltransferase 5,PRMT5)- 甲硫腺苷磷酸化酶(methylthioadenosine phosphorylase,MTAP)等组合备受关注。
ZY011Mu022甲硫腺苷磷酸化酶(MTAP)重组蛋白Recombinant Methylthioadenosine Phosphorylase (MTAP)Mus musculus (Mouse) ZY011Mu023脑源性神经营养因子(BDNF)重组蛋白Recombinant Brain Derived Neurotrophic Factor (BDNF)Mus musculus (Mouse) ZY011Mu024Runt相关转录因子2(RUNX2)重组蛋白Recombinant Runt Related Transcri...
The effects of MTA on cancer have also been studied. It has been extensively observed that MTAP (5′-methylthioadenosine phosphorylase) activity is lacking in many malignant cells, and that, in culture, these MTAP-deficient cells secrete MTA instead of metabolising it. As an example, internati...
Once adenosine 3′,5′-monophosphate (cyclic AMP) was established as the heat stable factor that mediated the activation of liver phosphorylase by epinephr... SJ Strada - 《Advances in Cyclic Nucleotide Research》 被引量: 170发表: 1982年 ...
2.4.2.28 S-methyl-5-thioadenosine S-methyl-5-thioadenosine + phosphate <=> adenine + S- phosphorylase methyl-5-thio-alpha-D-ribose 1-phosphate 2.4.2.7 Adenine AMP + diphosphate <=> adenine + 5-phospho-alpha-D-ribose phosphoribosyltransferase 1-diphosphate 2.7.8.25 Triphosphoribosyl- ATP + 3...
Heterologous Expression of 5′-Methylthioadenosine Phosphorylase from the Archaeon Sulfolobus solfataricus: Characterization of the Recombinant Protein and... The gene for the extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus was expressed at a...
The 5'-methylthioadenosine phosphorylase (MTAP) gene is located in the chromosomal region 9p21.MTAPdeletion is a frequent event in a wide variety of human cancers; however, its biological role in tumorigenesis remains unclear. The purpos... W Menezes,V Silva,I Gomes,... - 《Cells》 被引...