S-Methyl-5′-thioadenosine phosphorylaseEC number 2.4.2.28 Systematic name S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-α-d-ribosyl-transferase RecommenSpringer Berlin Heidelbergdoi:10.1007/978-3-540-49753-0_28
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Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway. It metabolizes a byproduct of polyamine synthesis, 5′-methylthioadenosine (MTA), leading to the regeneration of methionine and adenine. Homozygous deletion ofMTAP, the gene encoding this enzyme, occurs in...
目前,已发现了11种PRMT家族的成员,主要的研究热点集中在PEMT5上。 MTAP(methylthioadenosine phosphorylase,甲硫腺苷磷酸化酶)常与体内常见的抑癌基因CDKN2A发生共缺失现象,这种共缺失现象在肿瘤中的比例可达9%~15%。 PRMT5和MTAP是合成致死组合 2016年的两篇背靠背《Science》...
ZY011Mu022甲硫腺苷磷酸化酶(MTAP)重组蛋白Recombinant Methylthioadenosine Phosphorylase (MTAP)Mus musculus (Mouse) ZY011Mu023脑源性神经营养因子(BDNF)重组蛋白Recombinant Brain Derived Neurotrophic Factor (BDNF)Mus musculus (Mouse) ZY011Mu024Runt相关转录因子2(RUNX2)重组蛋白Recombinant Runt Related Transcri...
Enzyme deficiency and tumor suppressor genes: absence of 5'-deoxy-5'-methylthioadenosine phosphorylase in human tumors. genes 1 (cellular oncogenes) and the germline or somatic inactivation of tumor suppressor genes, also known as antioncogenes or recessive oncogenes 2 . ... FD Ragione,A Oliva...
Heterologous Expression of 5′-Methylthioadenosine Phosphorylase from the Archaeon Sulfolobus solfataricus: Characterization of the Recombinant Protein and... The gene for the extremely thermophilic and thermostable 5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus was expressed at a...
50-Deoxy-50- methylthioadenosine phosphorylase and p16INK4 deficiency in multiple tumor cell lines. Oncogene 1995;10:827–833. 30 Stadler WM, Olopade OI. The 9p21 region in bladder cancer cell lines: large homozygous deletion inactivate the CDKN2, CDKN2B and MTAP genes. Urol Res 1996;24:...
Three-Dimensional Structure of a Hyperthermophilic 5′-Deoxy-5′-Methylthioadenosine Phosphorylase from Sulfolobus Solfataricus*. J. Biol. Chem. 2001, 276, 39232–39242. [Google Scholar] [CrossRef] Kumar, S.; Nussinov, R. How do thermophilic proteins deal with heat? Cell. Mol. Life Sci. ...
In db/db mice, a model of early type 2 diabetes, treatment with an inhibitor of methylthioadenosine phosphorylase, which prevents conversion of a precursor to adenine, led to decreased pathologic changes in the mice, with decreases in cystatin C, serum creatinine, Kim-1, albuminuria, matrix, ...