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S-Methyl-5′-thioadenosine phosphorylaseEC number 2.4.2.28 Systematic name S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-α-d-ribosyl-transferase RecommenSpringer Berlin Heidelbergdoi:10.1007/978-3-540-49753-0_28
的作用下又重新生成SAM,从而完成整个AMC甲基循环(ActivatedMethylCycle)。病 原微生物和宿主细胞在S.腺苷高半胱氨酸代谢节点和AMC甲基循环中MTA节点的显 著差异,使病原微生物催化MTA和SAH裂解的SAHN核苷酶成为抗感染药物的潜在 靶点。 本实验以大肠杆菌基因组DNA为模板,通过PCR扩增目的基因sahn,构建 ...
ZY011Mu022甲硫腺苷磷酸化酶(MTAP)重组蛋白Recombinant Methylthioadenosine Phosphorylase (MTAP)Mus musculus (Mouse) ZY011Mu023脑源性神经营养因子(BDNF)重组蛋白Recombinant Brain Derived Neurotrophic Factor (BDNF)Mus musculus (Mouse) ZY011Mu024Runt相关转录因子2(RUNX2)重组蛋白Recombinant Runt Related Transcri...
近年来,PRMT5抑制与甲硫腺苷磷酸化酶(methylthioadenosine phosphorylase,MTAP)删除的“合成致死”逐步成为新的研究热点。MTAP通常与经典抑癌基因CDKN2A共同删除,发生于10-15%的肿瘤中,包括50%的脑胶质瘤和25%的胰腺癌。MTAP删除后,其底物MTA在肿瘤细胞内大量蓄...
(RNA interference, RNAi)和成簇的规律间隔的短回文重复序列(clustered regularly interspaced short palindromic repeats,CRISPR)基因编辑技术使基于“合成致死”的药物研究开启新的篇章;蛋白质精氨酸甲基 转移酶 5(protein arginase methyltra...
Nucleoside phosphorylases are important biocatalysts for the chemo‐enzymatic synthesis of nucleosides and their analogs which are, among others, used for the treatment of viral infections or cancer. S‐methyl‐5′‐thioadenosine phosphorylases (MTAP) are a group of nucleoside phosphorylases and the ...
Peter B. Illeil and Lorenzo Leoni and Weidong Huang and Stephanie Astrow and Alan Cheeks and Valerie Rusch and Marc LadanviLung CancerIllei PB, Leoni L, Huang W, et al. The methylthioadenosine phosphorylase (MTAP) gene is homozygously co-deleted with CDKN2A in most pleural mesotheliomas:...
Kamatani et al., " 5'-Methylthioadenosine Phosphorylase Deficiency in Malignant Cells: Recessive Expression of the Defective Phenotype in Intraspecies (Mouse x Mouse) Hybrids), " Adv. Exp. Med. Biol, 165(b):279-283, 1984.Kamatani et al., " 5'-Methylthioadenosine Phosphorylase Deficiency in...
The compounds and pharmaceutical compositions described are inhibitors of 5'-methylthioadenosine/S-adenosylhomocystein nucleosidase (MTAN) and/or 5'-methylthioadenosine phosphorylase (MTAP). Methods of treatment using the compounds and pharmaceutical compositions described are also provided for preventing ...