stagecompressor stageconditions stageconfiguration stageconstruction stagecontrol stage cooling stagecoutercurrentrea stage curing stagedcapacity stagedesign stagedevelopment stage diving stage dredging stagedresearch stage drive stage driving stage drop stage drying stageelectrodialysisu stage escape stageexcavation ...
The absolute configuration of the amino acid monomers in these compounds was determined by Marfey’s analysis49 combined with bioinformatic analysis of five dual C domains with epimerization and condensation activities50 in the Gdn NRPS assembly line (Fig. 1b, Supplementary Fig. 23, and Supplementary...
2a). Each CoIII ion is chelated in an octahedral geometry by two widely delocalized NOP chelators from two different ligands that are positioned in a mer configuration, equipping Co6L46+ with a robust coordination geometry and high stability. Deprotonated amide groups were located within the ...
It has been proposed that the fusogenic peptides in the HA trimer would bind the target membrane in a threefold symmetric configuration whereas oligomerization of HAs would cause the fusogenic peptides to associate in the target membrane and participate as an assembly in the fusion process (Cohen ...
2). Instead, CGN might have originally coded for an easier-to-produce positively charged amino acid, such as ornithine, a precursor to arginine (58, 60). Ornithine having a shorter side chain than arginine (or lysine) facilitates RNA–peptide interactions and discourages the formation of α-...
Fungal non-ribosomal peptide synthetase (NRPS)-encoding products play a paramount role in new drug discovery. Fusarium, one of the most common filamentous fungi, is well-known for its biosynthetic potential of NRPS-type compounds with diverse structural
The biological macromolecular world is homochiral and effective enforcement and perpetuation of this homochirality is essential for cell survival. In this study, we present the mechanistic basis of a configuration-specific enzyme that selectively removes D-...
DefinitionChEBI: (S)-3-amino-3-phenylpropanoic acid is an optically active form of 3-amino-3-phenylpropanoic acid having S-configuration. It is an enantiomer of a (R)-3-amino-3-phenylpropanoic acid. It is a tautomer of a (S)-3-ammonio-3-phenylpropanoate. ...
Capsule types are influenced by various factors, including the number and sequence of monosaccharide components, the position of glycosidic linkages, the configuration (L or D) of components, and the degree of chemical modification, such as O-acetylation. Consequently, capsular structures are diverse,...
). The relative configuration of syn-4B was assigned from the X-ray crystal structure of derivative 5B (Fig. 5d). A possible interconversion of (Z)-2c and (E)-2c has been excluded in several control experiments. Accordingly, we have developed a diastereoconservative variant in which the ...