3-Hydroxybutyryl-CoA dehydrogenase is an enzyme that catalyzes the second step in the biosynthesis of n-butanol from acetyl-CoA, in which acetoacetyl-CoA is reduced to 3-hydroxybutyryl-CoA. To understand the molecular mechanisms of n-butanol biosynthesis, we determined the crystal structure of 3-...
Cloning, expression, purification, crystallization and X-ray crystallographic analysis of (S)-3-hydroxybutyryl-CoA dehydrogenase from Clostridium butyricumdoi:10.1107/S2053230X14004348(S)-3-hydroxybutyryl-CoA dehydrogenaseClostridium butyricumn-butanol
protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3- hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the ...
Currently, the de novo synthesis of P(3HB-co-LA) has been successfully achieved by modifying microorganisms. The biosynthesis of P(3HB-co-LA) has been developed through the polymerization of two precursors 3-hydroxybutyryl-CoA (3HB-CoA) and lactyl-CoA catalyzed by Pseudomonas fluorescens 2P24...
Finally, 3-hydroxyacyl-CoA dehydrogenase would convert S-3-hydroxybutyryl-CoA into acetoacetyl-CoA (Bd1836) [EC 1.1.1.35 (http://www.genome.jp/kegg-bin/show_pathway?bba00650)], which channels into central metabolism, thus explaining the increase in predator progeny after preying on PHB-...
中文名称:(S)-3-羟基丁酸 英文名称:(3S)-3-hydroxybutanoic acid CAS No.:6168-83-8 分子式:C4H8O3 分子量:104.1045 如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:(S)-3-羟基丁酸结构式 下载该化合物MOL文件:(S)-3-羟基丁酸MOL ...
(ETF) and the second pair is generated from the oxidation of 3-hydroxybutyryl-CoA to acetoacetyl-CoA (E0′ = −250 mV) which is directly used to reduce NAD+. The first electron pair have high redox potential (E0′ = −125 mV), which can be only used by the ...
For compounds that are not commercially available (2-methylacetoacetate, 3-hydroxybutyrylcarnitine, 3-hydroxyisovalerylcarnitine and hawkinsin), MS parameters were found and optimised from patient urine samples. First, MS spectra were found online [21], and preliminary MRM transitions were generated....
and 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), were significantly lower in BDL mice compared to ShamOP mice (Fig.3b, linear model, FDR < 0.05). Overall, the functional potential of the microbiome in BDL mice was greatly affected, including a reduction in the production of anti-inf...
Furthermore, inherited HADH2 mutations lead to 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency, which is characterized by neurological abnormalities (Ofman et al., 2003). Download: Download full-size image Figure 4. Functional Characterization of Cys58 of HADH2 (A) Structure of HADH2 (PDB...