今天推荐的是由贵州医科大学附属医院神经外科在2023年4月22日发表于Cell Death and Disease(2021IF:9.6963,JCRQ1)的一篇文章,通讯作者是Liangzhao Chu教授,研究表明USP10对RUNX1进行去泛素化,促进胶质母细胞瘤的骨架-间质转化。 研究背景 胶质母细胞瘤(GBM)的间质(MES)亚型是一种高度侵袭性、恶性和增殖性的癌症,...
We found in wild type (WT) mice that anergic T cells, defined by co-expression of the cell surface markers CD73 and FR4, express lower expression of the transcription factor Runx1. To test if Runx1 acts as a negative regulator of the anergy program, we utilized a 1:1 mixed bone ...
写在前面 今天推荐的是由贵州医科大学附属医院神经外科在2023年4月22日发表于Cell Death and Disease(2021IF:9.6963,JCRQ1)的一篇文章,通讯作者是Liangzhao Chu教授,研究表明USP10对RUNX1进行去泛素化,促进胶质母细胞瘤的骨架-间质转化。 研究背景 胶质母细胞瘤(GBM)的间质(MES)亚型是一种高度侵袭性、恶性和增殖...
RUNX1 mutations are associated with poor prognosis in patients with acute myeloid leukemia or adult T-cell acute lymphocytic leukemia. In younger (\u003c60 years old) AML patients, allogeneic stem cell transplant at complete remission led to much better relapse-free survival than repetitive cycles ...
最近有研究表明,突变型 RUNX1 是某些类型白血 病细胞生长和存活所必需的,通过在小鼠和造血细胞中 探讨了 RUNX1 是否直接参与造血细胞对细胞毒性剂 的反应,发现 RUNX1 在转录后被细胞毒性剂上调,在 体外用阿糖胞苷处理后,在原发性 AML 细胞中也观察 到上调,说明在 AML,骨髓增生异常综合征和 T 细胞急 性淋巴...
but they do not exhibit the cytological or cytochemical abnormalities characteristic of AML with inv(16)(p13.1q22) or t(16;16)(p13.1 ;q22); basophils and/or mast cells are sometimes present in excess. Concurr...
【翻译】急性髓系白血病伴t(8;21)(q22;q22.1);RUNX1-RUNX1T1的特征是:核周淡染区(凹陷),非常大的颗粒(假切东颗粒),原始细胞中单根细长而一端削尖的棒状小体。 A 34-year-old woman presented with dyspnea for 2 weeks. 【翻...
结果15例(10 34%)患者中检出RUNX1突变。与RUNX1wt组(n=130)患者相比,RUNX1mut组(n=15)患者的年龄更大[(61.00±10.42)岁,(49.92±16.33)岁](t=3.63,P=0.001),骨髓原始细胞比例更低[34.01(22.60,45.00)%,55.91(33.44,77.95)%,U=827.00,P=0.013],AML细胞表达CD15[0%(0/15),26.15%(34/130),P=...
remission,CR1)接受异基因造血干细胞移植(allogeneichematopoieticcelltransplantationAllo-HCTRUNX1::RUNX1T1AML,)在阳性的预后意义,以期改善这类患者的预后。【方法】1.收集2012.01.01至2022.12.31本中心就诊的571例RUNX1::RUNX1T1阳性AML患者,总结其临床资料以及细胞遗传学、分子生物学等实验室资料并进行...
ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease. Blood. 1996;88(5):1813–23. Article CAS PubMed Google Scholar Steinauer N, Guo C, Zhang J. Emerging roles of MTG16 in cell-fate control ...