Because prespecified criteria cannot always predict which patients will and will not derive benefit, run-in periods, which may be used for other reasons as well, are often incorporated into the design to enrich the sample by detecting and excluding a subgroup of the study population that is ...
A run-in phase may be included in clinical trials in oncology, immune diseases, infections, metabolic diseases, and nutritional intervention, to give a few examples. The run-in phase is part of the study design, and it may be depicted in the study schema. This chapter details a dozen sepa...
The run-in period in clinical trials. The effect of misclassification on efficiency. This article considers the effect of misclassification of potential participants during the run-in period preceding randomization in a clinical trial. We p... E Brittain,J Wittes - 《Controlled Clinical Trials》 ...
A run-in is a period prior to randomization during which potential participants who have met all entry criteria for a randomized clinical trial are assigne... Vance W Berger Ph.D. a b,Azadeh Rezvani a c,Vanessa A Makarewicz a d e - 《Controlled Clinical Trials》 被引量: 105发表: 2003...
A direct comparison of adverse events between group for the run-in period and mean monthly events during the trial showed no difference. The 244 patients who remained in the study after the run-in period were randomized to continue receiving the inhaled corticosteroid or to receive placebo. We ...
53. a distance covered by running or a period of running: a run of ten miles. 54. (Automotive Engineering) an act, instance, or period of travelling in a vehicle, esp for pleasure: to go for a run in the car. 55. free and unrestricted access: we had the run of the house and...
one or both arms may be advanced to Stage 2 during which 17 additional evaluable patients/per arm will be enrolled.Results:The 3-patient safety run-in for both arms of Cohorts 5 (6 patients total) have been enrolled, and all patients have completed the required 1-month evaluation period. ...
length of the run-in period used for determining treatment status, except when using the naive and methodologically flawed run-in period of variable length... H Støvring,M Andersen,H Beck-Nielsen,... - 《Population Health Metrics》 被引量: 33发表: 2007年 Re-reading the Israelite Jubilee ...
However, the proposed design loses some of its advantage when the proportion of potential responders is large (>50%) or the effect on survival from run-in period is substantial.Incorporating a pharmacodynamic biomarker requires careful consideration but can expand the capacity of clinical trials to ...
Today we’re going to look at the ongoing studies and clinical trials specific to soft tissue sarcomas in adults. The below list was curated by assessing the ongoing Phase 3 trials for soft tissue sarcomas, specific to adults, and based in the United States. The dates provided are estimates...