1.Yanlin Song, Targeting RAS-RAF-MEK-ERK signaling pathway in human cancer: Current status in clinical trials. Genes & Diseases, 2023.https://doi.org/10.1016/j.gendis.2022.05.006 2.Anica Dricu, et al. Epigenetic Alteration of Re...
Pointed (Pnt), an ETS transcriptional activator functions downstream of the Receptor Tyrosine Kinase (RTK) signaling pathway to regulate diverse processes during the development of Drosophila. This review highlights the indispensable role that Pnt plays in regulating normal development and how continued ...
12. Pan, D. (2010). The hippo signaling pathway in development and cancer. Developmental Cell. https://doi.org/10.1016/j.devcel.2010.09.011 13. Gumbiner, B. M., & Kim, N. G. (2014). The Hippo-YAP signaling...
Prostate cancer lineage plasticity is a key driver in the transition to neuroendocrine prostate cancer (NEPC), and the RTK/RAS signaling pathway is a well-established cancer pathway. Nevertheless, the comprehensive link between the RTK/RAS signaling pathway and lineage plasticity has received limited ...
Discoidin domain receptor 1 expression in activated T cells is regulated by the ERK MAP kinase signaling pathway[J]. Journal of cellular biochemistry, 2011, 112(12): 3666-3674.[13] Sun X, Gupta K, Wu B, et al. Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by...
Importantly, inhibition of EGFR also leads to activation of STAT3 via an IL-6 pathway15. As for YAP, an extensive cross talk between EGFR signaling and YAP has been reported57. The EGFR signaling pathway positively regulates YAP via MEK-ERK signaling and YAP signaling contributes to resistance ...
Results::GO and KEGG enrichment analyses revealed the involvement of HIF-1, Akt signaling pathway and energy metabolism-related signaling pathways. Molecular docking results emphasized eight key compounds and confirmed their interactions with corresponding targets. In vitro OGD/R model experiments ...
Advances in molecular mechanisms and targeted therapy of gastric cancer associated with the RTK/RAS signaling pathway 引用 收藏 分享 摘要 目的了解RTK/RAS信号通路相关胃癌的分子机制及靶向治疗研究进展,以期为部分胃癌患者的治疗提供借鉴。方法对近年来国内外关于RTK/RAS信号通路相关胃癌的分子机制及靶向治疗研究的...
SPRY4 Antibody is a Rabbit Polyclonal antibody against SPRY4. SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS. ...
Studies in C. elegans have provided much insight into the basic framework of this RTK/Ras/MAPK signaling pathway, its regulation, how it elicits cell-type specific responses, and how it interacts with other signaling pathways such as the Wnt and Notch pathways. 展开 ...