Tan, PBO, Kim, SK (1999) Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans. Trends Genet 15: pp. 145-149Tan PB, Kim SK: Signaling specificity: the RTK/RAS/MAP kinase pathway in metazoans. Trends Genet 1999, 15: 145–149....
3 细胞生物学RTK
Discoidin domain receptor 1 expression in activated T cells is regulated by the ERK MAP kinase signaling pathway[J]. Journal of cellular biochemistry, 2011, 112(12): 3666-3674.[13] Sun X, Gupta K, Wu B, et al. Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by...
One of the most common intracellular signaling pathways triggered by RTKs is known as the mitogen-activated protein (MAP) kinase cascade, because it involves three serine-threonine kinases. The pathway starts with the activation of Ras, a small G protein anchored to the plasma membrane. In its...
(C) Heatmap showing genes that were significantly upregulated in the ‘‘KRAS signaling up’’ gene set from (B). (D) GSEA showing the significantly enriched KRAS signaling pathway comparing KMT2D-low versus KMT2D-hi...
Prostate cancer lineage plasticity is a key driver in the transition to neuroendocrine prostate cancer (NEPC), and the RTK/RAS signaling pathway is a well-established cancer pathway. Nevertheless, the comprehensive link between the RTK/RAS signaling path
Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) signaling pathways are used repeatedly during metazoan development to control many different biological processes. In the nematode Caenorhabditis elegans, two different RTKs (LET-23/EGFR and EGL-15/FGFR) are known to stimulate LET-60/Ras...
RTK-Ras-MAP kinase pathway Grb2+Sos MAPK (mitogen activated protein kinase):有丝分裂原活化蛋白激酶 Activated MAPK enters nucleus, phosphorylates txp factor Jun fos, regulates cell proliferation 在25 %~30 %的人肿瘤中,发现异常的Ras蛋 白(其12或61位残基发生点突变),抑制Ras 本身GTPase的活性,不...
Protein Tyrosine Kinase Signaling Pathway MapAll rights reserved. Any unauthorized use or reproduction without permission is prohibited.Tags: rtk inhibitor | RTK inhibitors | Protein Tyrosine Kinase Inhibitor | protein tyrosine kinases | tyrosine kinase activation | tyrosine kinase signaling | tyrosine ...
DNA-Dependent Protein Kinase DNA-PK DNMTs DOP Receptors Dopamine D1 Receptors Dopamine D2 Receptors Dopamine D2-like, Non-Selective Dopamine D3 Receptors Dopamine D4 Receptors Dopamine D5 Receptors Dopamine Receptors Dopamine Transporters Dopaminergic-Related ...