DS-Cav1是一种由NIAID/NIH开发的使用稳定化pre-F的亚单位疫苗,其I期结果为基于结构的疫苗设计提供了概念验证。疫苗接种导致血清中和活性增加了10倍以上,并可持续整个RSV季节。另外两个候选疫苗使用稳定化的pre-F蛋白作为疫苗抗原。RSVpreF(PF-06928316)是一种双价(亚型A...
在一些实施方式中,突变rsvf分子包含在第198位氨基酸处(或与其对应的氨基酸位置——例如通过与seqidno.1比对,和/或使用seqidno.1的氨基酸编号来确定)的酪氨酸,与在第226位氨基酸处(或与其对应的氨基酸位置——例如通过与seqidno.1比对,和/或使用seqidno.1的氨基酸编号来确定)的酪氨酸之间的二酪氨酸交联。 在一...
(RSV) infection in Germany: a systematic review Anahita Poshtiban1* , Moritz Wick1 , Mathieu Bangert2 and Oliver Damm1 Abstract Background Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory infection and...
discovered that mRNA/LNP vaccine candidates expressing either prefusion stabilized or native forms of RSV F protein elicit robust neutralizing antibody responses in both mouse and cotton rat, similar to levels observed with a comparable dose of adjuvanted prefusion stabilized RSV F protein (DS-Cav1)....
辉瑞的RSV疫苗使用了双价抗原,分别来自RSV A与RSV B病毒亚型的Pre-F蛋白;葛兰素史克的RSV疫苗抗原则以DS-Cav1为基础,通过引入半胱氨酸残基稳定在其融合前构象,形成二硫键,从而稳定蛋白质的构象或寡聚状态(DS-Cav1是2013年中美科学家联合设计的Pre-F抗原)。
The RSV vaccine candidate, DS-Cav1-I53-50, is a stabilized pre-F protein nanoparticle vaccine that was evaluated in rhesus macaques and found to be highly immunogenic [304]. Another RSV nanoparticle vaccine candidate, i.e., pre-F-NP, a modified pre-F stabilized protein fused to ferritin ...
歼20B性能参数 歼20B的性能参数主要包括以下几个方面: 机体尺寸:长度为20.4米,翼展为13.5米,高度为4.45米,翼面积为78平方米。12 重量参数:空重约为19吨,最大起飞重量约为37... jform2.baidu.com/s?wd=歼20B性能参数...歼20B性能参数_百度搜索 歼20B性能参数 歼20B的性能参数主要...
A340-500是“新一代”中的超长航程型,原为全球续航距离最长的商用客机(DC-10空中加油机为目前续航距离最长的飞机),直至2006年初才被波音777-200LR Worldliner所取代。其翼展面积与A340-600相同。A340-500能在三级客舱运载313名乘客的情况下飞越超过8,650......
The RSV vaccine candidate, DS-Cav1-I53-50, is a stabilized pre-F protein nanoparticle vaccine that was evaluated in rhesus macaques and found to be highly immunogenic [304]. Another RSV nanoparticle vaccine candidate, i.e., pre-F-NP, a modified pre-F stabilized protein fused to ferritin ...
The RSV vaccine candidate, DS-Cav1-I53-50, is a stabilized pre-F protein nanoparticle vaccine that was evaluated in rhesus macaques and found to be highly immunogenic [304]. Another RSV nanoparticle vaccine candidate, i.e., pre-F-NP, a modified pre-F stabilized protein fused to ferritin ...