Gastro-intestinal tumours in rats and mice following various routes of administration of N-methyl-N-nitroso-N'-nitroguanidine and N-ethyl-N-nitroso-N'-nitroguanidine. ImagesFigs. 4-5Figs. 6-7Figs. 1-2Figs. 8-9Fig. 3 R Schoental,JP Bensted - 《Br J Cancer》 被引量: 421发表: 1969年...
Impact of tissue factor expression and administration routes on thrombosis development induced by mesenchymal stem/stromal cell infusions: re-evaluating the dogma Van T. Hoang, Duc Son Le, Duc M. Hoang, Trang Thi Kieu Phan, Lan Anh Thi Ngo, Trung Kien Nguyen, Viet Anh Bui & Liem...
Administration of vasopressin via ETT or IN did not change hemodynamic parameters and had significantly lower maximum plasma concentrations and systemic absorption compared to piglets administered IV vasopressin (p < 0.05). The IV and IO routes appear the most effective for vasopressin administration...
Oral administration of analgesic agents is simple and noninvasive and has shown good efficacy in most settings, with high patient acceptability and similar efficacy as the IV route. Vomiting or delayed gastric emptying are a contraindication to oral administration. Indeed, if the oral route is used...
Figure 2. MRI of the brain of a patient with Canavan disease pre and post gene transfer therapy Coronal T2W images of the brain at baseline (A and F) and 90-, 180-, 365-, and 730-day follow-up at the levels of anterior frontal white matter (A–E) and body of the corpus callosu...
Interferon gramma release assay (IGRA) responses of animals vaccinated with M. bovis BCG via different routes of administration. A Phase 1, B Phase 2. Data are presented as ΔOD with ≥ 0.1 used as cut-off Full size image Tuberculin skin testing results Prior to vaccination 9/11 animal...
26,27 These promising results open up the field of gene therapy to numerous neurodegenerative diseases, giving a renewed hope to find a cure. However, the vast majority of the encouraging results in the preclinical model were obtained after administration of the therapeutic vector into the cisterna...
Highly efficient adeno associated viruses (AAVs) targeting the central nervous system (CNS) are needed to deliver safe and effective therapies for inherited neurological disorders. The goal of this study was to compare the organ-specific transduction eff
nervous system cells. In immunocompromised, neonates and young children, these viral infections can manifest as severe diseases, such as encephalitis, meningitis, and acute flaccid paralysis. What confers this remarkable plasticity and makes them efficient in infecting cells of the gut and the brain ...
Most previous studies attempting to prove the phenomenon of mother-to-infant microbiota transmission were observational, performed only at genus/species-level resolution, and relied entirely on non-culture-based methodologies, impeding interpretation. Results This work aimed to use a biomarker strain, Bif...