W. The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res. 60, 3927–3939 (2000). CAS PubMed Google Scholar Zhong, W. et al. Inhibition of cell growth and sensitization to oxidative damage by ...
Cancer formation is a complex and highly regulated multi-step process which is highly dependent of its environment, from the tissue to the patient. This complexity implies the development of specific treatments adapted to each type of tumor. The initial step of cancer formation requires the ...
The role of adipocytes as modulatory cells in the micro-environment immune cells/stem cells is particularly intriguing to assess how reactive oxygen species (ROS) play a signaling task in the fine tuning of cell-to-cell communication in a tumor environment. This cross talking should have a major...
Indeed, ROS intervene in numerous cellular processes and clearly participate in chronic inflammation and have been clearly involved in the establishment of a pro-inflammatory, tumor-prone environment55–65. To conclude, the results presented in this study indicate that A3A exerts far more complex ...
Engagement of a subset of Toll-like receptors (TLR1, TLR2 and TLR4) results in the recruitment of mitochondria to macrophage phagosomes and augmentsmitochondrial ROSproduction for bacterial killing. A TLR signaling adaptor, tumor necrosis factor receptor-associated factor 6 (TRAF6), translocates to ...
Although there is a strong correlation between multinucleated cells (MNCs) and cancer chemo-resistance in variety of cancers, our understanding of how multinucleated cells modulate the tumor micro-environment is limited. We captured multinucleated cells from triple-negative chemo-resistant breast cancers...
evokes p53 and transcriptional activation as exemplified by downregulation of Bcl-2 expression and up-regulation of the Bax, fas, and Apaf1 expression [283]. Some researchers suggest that depending on the p53 levels, the effect might differ from survival, tumor suppression, or cell death [284]....
(ROS)mainlyproducedbyoxidativestress,notonlycausesDNAdamageandgenetic unstability,butalsocloselyinvolvesinorganlesionandtumordevelopment.Recently,takingadvantageofROSdifference betweenthenormalcellsandtumorcells,ROSresponsivenano-deliverysystemisdesigned.Drugsonlyreleasewithinthetumor micro-environmentathighlevelofROS,...
Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment Article Open access 30 April 2021 All organic nanomedicine for PDT–PTT combination therapy of cancer cells in hypoxia Article Open access 30 July 2024 Advances in smart nanotechnology-supported photodynamic...
suggesting that the release of OLE was significantly accelerated at acid environment in the presence of H2O2due to the pH-induced PEG de-shielding and ROS induced hydrophilic transition of thioether, resulting in the disruption of nanoparticles. Mice were immunized intravenously with the tumour lyste...