Platinum nanoparticles (PtNPs) offer significant promise in cancer therapy by enhancing the therapeutic effects of platinum-based chemotherapies like cisplatin. These nanoparticles improve tumor targeting, reduce off-target effects, and help overcome drug resistance. PtNPs exert their anti-cancer effects ...
This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee on the Use of Animals (CEUA) from UFRGS (project number 32807). Competing interests The authors declare no competing interests. Additional information Publisher’s note...
Dong YanBeijing Luhe Hosiptal, Capital Medical Uiniversity, Peiking, China;Mengxiang XuGenetron Health (Beijing) Technology, Beijing, China;Weiran WangGenetron Health (Hangzhou) Medical Laboratory Co. Ltd., Hangzhou, China;Yushuai HanGenetron Health (Beijing) Technology, Beijing, China;Jianhua Zhu...
In our model, as expected, the menadione treatment led to production of mitochondrial superoxide as well as hydrogen peroxide that was visualized both in mitochondria and cytosol (Fig. 1A, Supplementary Videos 1-3; note that in the further text, the term ROS is used to refer these species)....
Zearalenone (ZEN), an estrogenic mycotoxin, is one of the most common food and feed contaminants. Also, its metabolites α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL) are considered to induce oxidative stress, however its effect in prostate cells is n
note, theROS1G2032R resistance mutation was no longer detected in the autopsy sample. Additional variants were detected inRB1(splice region/intronic variant; c.2520 3G > T) andFLT3(S497W; c.1490C > G); these genes had not been evaluated in the NGS analysis of the prior ...
Effect of reactive oxygen species （ROS ）on bone destruction in rheumatoid arthritis GUO Wan -Yi ，YUAN Bei ，ZHANG Ni -Xue ，KONG Xiang -Ying ，SU Xiao -Hui ，LIN Na.Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences ，Beijing 100700，China ［Abstract ］Objective ...
industrial action, natural disaster, technical problems with transport, or other events beyond our control including those mentioned in the preceding paragraph; participants' medical or psychiatric conditions which may develop during or subsequent to the holiday; loss of, or damage to, personal property...
Note: All p-values calculated by using Fisher’s exact test. PD-L1, programmed death ligand 1; IHC, immunohistochemistry; TPS, tumor proportion score; FNA, fine-needle aspirate; ALK, anaplastic lymphoma receptor tyrosine kinase gene; FISH, fluorescence in situ hybridization. a Lung versus other...
ROS1-rearranged lung cancers benefit from first-line crizotinib therapy; however, clinical and molecular factors that could affect crizotinib efficacy in ROS1-rearranged lung cancers are not yet well-elucidated. Our retrospective study aimed to compare the efficacy of chemotherapy and crizotinib in the...