identifying new targets and inferring the mechanism of action: taking rhein as an example Hao Sun1,2, Yiting Shen1, Guangwen Luo1, Yuepiao Cai1* and Zheng Xiang1* Abstract Background: Target identification is necessary for the comprehensive inference of the mechanism of action of a compound....
Target identification is necessary for the comprehensive inference of the mechanism of action of a compound. The application of computational methods to predict the targets of bioactive compounds saves cost and time in drug research and development. Ther
Rosmarie Süß, Kristin Teuber, Martin Schürenberg, Detlev Suckau & Jürgen Schiller 1824 Accesses Explore all metrics Abstract Phospholipids (PL) are increasingly analyzed by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). As in the case ...
Unfortunately, such correction methods may trade sensitivity for proper family-wise error rates, potentially inflating the probability of Type-II errors. A second issue with AFQ-derived diffusion statistics we note is the distribution of values for any given tract may not meet the requisite normality...
Also here for the Methods 1 and 3 (Fig. 2c) the same result was found, Cys45 donates a H-bond to the backbone oxygen of Leu39, while Method 2 finds no H-bonds. Important to note is that the H-bond cutoff settings used in Method 1 can be easily changed by the user. ...
MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging – design, implementation and application on the example of DCE-MRI Charlotte Debus, Ralf Floca, Michael Ingrisch, Ina Kompan, Klaus Maier-Hein, Amir Abdollahi & Marco Nolden BMC Bi...
CAT(the catalase gene) is known as an important antioxidant enzyme that breaks down hydrogen peroxide to oxygen and water, lowering the impact of ROS (reactive oxygen species) alleviating the negative effect of carcinogenesis, and providing skin protection against radiation and UV [23]. Rs1001179...
of the answers provided by ChatGPT in relation to statistical analysis, as well as to identify recommendations to be implemented in the future in connection with the results obtained. Methods: The study was divided into four parts and was based on the exemplary medical field of allergology. The...
Everything that mainly presents itself as an adversarial example paper is listed here; I pass no judgement of quality. For a curated list of papers that I think are excellent and worth reading, see the Adversarial Machine Learning Reading List. One final note about the data. This list ...
Building a 3D VR tree-felling simulator requires a lot of time and resources, while a text-based sim (a la Twine) probably isn’t enough for this task (Or is it?). Cathy, what are the simplest simulation approaches that are also reasonably effective? Note, I ask more about approach ...