The problem of excessive aluminum (Al) content in food is widespread. After Al enters the body, it can cause mineral metabolism imbalance and reactive oxygen species (ROS) overproduction, which ultimately leads to bone impairment. ROS is mainly produced in mitochondria and acts on mitochondria. ...
In this chapter, we describe a relation between mitochondrial membrane potential and the rate of ROS formation. We present different methods applicable for isolated mitochondria or intact cells. We also present experiments demonstrating that a magnitude and a direction (increase or decrease) of a ...
A new asymmetric total synthesis of a phenanthroindolizidine alkaloid (S)-tylophorine is reported, which features a catalytic asymmetric allylation of aldehydes and an unexpected one-pot DMAP promoted isocyanate formation and Lewis acid catalyzed intramolecular cyclization reaction. In addition, White's...
This regenerative cycle of mitochondrial ROS formation and release was named ROS-induced ROS release (RIRR). Brief, reversible mPTP opening-associated ROS release apparently constitutes an adaptive housekeeping function by the timely release from mitochondria of accumulated potentially toxic levels of ROS...
In the research of heart failure, people found that ROS could affect the formation and development of heart failure in many pass ways.Here we are going to discuss those pass waysand clinical meaningsin a more comprehensive manner. Key words:ROS, mitochondria, heart failure 1.ROS的产生与清除 ...
Reactive oxygen species (ROS) originating from mitochondria are perceived as a factor contributing to cell aging and means have been sought to attenuate ROS formation with the aim of extending the cell lifespan. Silybin and dehydrosilybin, two polyphenolic compounds, display a plethora of biological...
resulting in a positive feedback process that amplifies its damage [43]. In contrast, uncoupling proteins (UCPs) decrease the membrane potential of mitochondria in oxidative phosphorylation, which attenuates ROS production and promotes cytoprotection, including in the aging process [44]. UCPs are tra...
the formation of myotubes,ST3,RCR,MyHCⅠ,MyHCⅡa and MyHCⅡx mRNA expression,MyHC,PGC-1α,Tfam,COXⅣ,and MnSOD protein expression in group ON significantly decreased(P 0.05~0.01).ST4,cytoplasmic ROS,mitochondrial ROS generation and MyHCⅡb mRNA in group ON significantly enhanced(P 0.05~0.01...
7D, E). While the exact mechanisms for hyperglycemia-elevated ROS production in mitochondria is yet to be determined, it has been shown that during canonical necroptosis RIP1, RIP3, and MLKL translocate to the mitochondria and stimulate ROS production38. From an in vivo perspective, cerebral ...
We extended our studies of the effect of glucose starvation on Myo19, and found that the localization of Myo19 and mitochondria to filopodia tips is mediated by ROS. Tracking Myo19 localization during ROS-induced filopodia formation, revealed its inducible motor activity that strongly supports active...