Here, we report that hypoxia-induced factor 1 alpha (HIF1 alpha) is the master transcription factor for Il10 in ROR gamma t+ Tregs. This critical anti-inflammatory pathway is negatively regulated by an RNA binding protein DEAD box helicase 5 (DDX5). As a transcriptional corepressor, DDX5 ...
by expression of specific transcription factors, T-bet for Th1, GATA-3 for Th2, forkhead box P3 (FoxP3) for Tregs and RORgammat for Th17 cells. ... B Afzali,G Lombardi,RI Lechler,... - 《Clinical & Experimental Immunology》 被引量: 1216发表: 2010年 ...
This results in upregulation of the transcriptional modulator FoxP3 resulting in CD4+FoxP3+ Tregs. In case the naïve T-cells are co-stimulated by IL-6, FoxP3 expression is suppressed and RORγt expression is induced. These CD4+FoxP3−RORγt+ T-helper cells then differentiate into IL-...
These findings suggest that synthetic agonists of RORgammat should activate T c 17/T H 17 cells, decrease the population of Tregs, repress PD-1, and produce IL17 in situ , an immune factor associated with good prognosis in cancer.GRIFFIN, Patrick...
Multiple subsets of Tregs expressing master transcription factors of helper T cells such as ROR gamma t, T-bet, Gata3 and PPAR gamma have been characterized, but the molecular mechanism governing the differentiation of these subsets remains largely unknown. Here we report that the atypical I ...