FamilyRoleSick RoleIn our department, which is structured as a 'therapeutic community', we often receive as patients women living with alcoholics. To be able to identify key figures in their milieu, we have found Eric Berne's description of the alcoholic's relational network both covering and ...
The Children's Roles Inventory (CRI) is a 60-item measure designed to assess four roles hypothesized to be an important part of the alcoholic family system. The four childhood roles are (a) the Hero, (b) the Mascot, (c) the Lost Child, and (d) the Scapegoat. Using data from three...
In 1987, we began a longitudinal study of the offspring of alcoholic parents and have been following this group of young adults from their freshman year in... KJ Sher,HJ Gotham - 《Development & Psychopathology》 被引量: 305发表: 1999年 Childhood and adolescent predictors of heavy drinking an...
Genetic, metabolic, lifestyle, and dietary patterns are among the most influential determinants of T2DM [6]. Although ethnicity and family history/genetic predisposition have a substantial genetic basis for developing T2DM, epidemiological studies indicate that T2DM can be prevented by improving modifiable...
(MCD) diet-induced nonalcoholic steatohepatitis (NASH) mice [153], and in patients with human liver cirrhosis (LC) [154]. Hepatic infiltrating Th22 cells and their cytokine IL-22 can attenuate hepatic stellate cell activation, achieving protective effects and ameliorating fibrosis [152]. Similarly...
In addition, FoxA1 has also been considered as a novel therapeutic target for triglyceride accumulation on non-alcoholic fatty liver (NAFL) due to its ability of inhibiting hepatic triglyceride synthesis, accumulation and secretion [199]. Furthermore, FoxA1 also repressed fatty acid transporter protei...
The inhibition of heat shock protein 90 beta (HSP90β) facilitates the ubiquitination and proteasomal degradation of mature sterol regulatory element-binding proteins (SREBPs), leading to the amelioration of lipid metabolism disorders in patients with nonalcoholic fatty liver disease (NAFLD) and diet-...
For example, insufficient fatty acid uptake and utilization lead to malnutrition, whereas excessive lipid storage and hyperlipidemia are involved in atherosclerosis, obesity, and non-alcoholic fatty liver disease (Liu et al. 2021b; Lu et al. 2021). A better understanding of the factors that ...
and yet is found elevated in patients with rheumatoid arthritis59, hypertension90, non-alcoholic fatty liver disease (NAFLD)87,91and inflammatory bowel disease92. However, these observations may be confounded by previously unrecognized diversity within theS. copricomplex. Our study did not find any ...
Myocardial infarction, commonly known as a heart attack, is a serious condition caused by the abrupt stoppage of blood flow to a part of the heart, leading to tissue damage. A significant aspect of this condition is reperfusion injury, which occurs when