In addition, one in eight individuals, or an estimated 30 million adults, has an alcoholic parent. The literature suggests that the impact of growing up in an alcoholic family system may affect psychological functioning well into adulthood. Adult children of alcoholics (ACOAs) are at increased ...
Children in alcoholic families are exposed to destructive patterns of behaviour. To adapt to difficult situations and survive, they play various roles. However, these roles, when transferred into adulthood, act against them. Adult children of alcoholics live with the stigma of co-dependency rooted ...
Even when parents do their best at loving and respecting all of their children, the influence of siblings on one another can be enormous. Brothers and sisters spend more time together during childhood than with their parents, particularly today when nearly 60 percent of mothers with children under...
Mothering is generally considered women’s major source of identity and satisfaction. But mothering can also bring misery when children develop anti-s
Fetal alcohol exposure (FAE) is the leading preventable developmental cause of cognitive dysfunction. Even in the absence of binge drinking, alcohol consumption during pregnancy can leave offspring deficient. However, the mechanisms underlying these defi
of close-knit family with Midwestern values, who was raised when few questioned family togetherness and when many children stayed close to home, she may balk at your choice to live thousands of miles from home.Beyond the desire to lead a life independent of parents, opposing values an...
We found that rare PTVs inAPBA1andBSNwere associated with a substantial increase in adult BMI and higher risks of obesity and severe obesity in adults. Rare PTVs inBSNwere also associated with higher risks for T2D and nonalcoholic fatty liver disease. The associations with adult BMI were conf...
Mutations in the PTPN11 gene are associated with various developmental disorders, hematologic malignancies, and solid tumors, playing distinct biological roles in different mechanisms of cancer development [12,13]. Through the PI3K/AKT/GSK3β signaling pathway, PTPN11 has been shown to promote the pro...
The gut microbiome plays important roles in the maintenance of health and pathogenesis of diseases in the growing host. In order to fully comprehend the interplay of the gut microbiome and host, a foundational understanding of longitudinal microbiome, in
microbe–microbe and microbe–host interactions Keywords: dietary perturbations; gut microbiota; obesity; resilience Introduction Obesity and related metabolic diseases, such as type 2 diabetes, angiocardiopathy and nonalcoholic fatty liver, have become a devastating epidemic world- wide (Popkin, 2007). ...