Proteins are large complex molecules that are made up of one or more amino acid residues and are present in all living cells. Proteins as a nutrient are more commonly found in high amounts in animal products, but there are plant sources...
Our findings expand the repertoire of PP1 functions during mitosis and indicate that spatiotemporal changes in the distribution of kinases and counteracting phosphatases finely tune the activity of cytokinesis proteins.doi:10.1038/s41467-019-12507-9Luisa Capalbo...
HMGA proteins exert their oncogenic activity through several mechanisms: induction of E2F1 and AP1 activity, induction of cyclin A expression, inactivation of p53-induced apoptosis, impairment of DNA repair, enhancement of the expression of proteins involved in inflammation, and modulation of the express...
Adolescent depression is becoming one of the major public health concerns, because of its increased prevalence and risk of significant functional impairment and suicidality. Clinical depression commonly emerges in adolescence; therefore, the prevention a
Glycine, proline, and hydroxyproline (Hyp) contribute to 57% of total amino acids (AAs) in collagen, which accounts for one-third of proteins in animals. As the most abundant protein in the body, collagen is essential to maintain the normal structure and strength of connective tissue, such...
Lipid droplets (LDs), which are active organelles, derive from the monolayer membrane of the endoplasmic reticulum and encapsulate neutral lipids internally. LD-associated proteins like RAB, those in the PLIN family, and those in the CIDE family particip
O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a common and important post-translational modification (PTM) linking O-linked β-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues in proteins. Extensive research indicates its impact
In addition, GJIC and Cxs are associated with the grade and stage of cancer [21–24], with abnormal expression and subcellular localization of Cxs being asso- ciated with cancer initiation and progression. Post-trans- lational modifications (PTMs) of proteins, which occur via phosphorylation, ...
The high prevalence of these tumours, lack of effective biomarkers and limited effective treatment options highlight the importance of basic research in these diseases. Galectins are a family of β-galactoside-binding proteins that are frequently altered (upregulated or downregulated) in a wide range...
The role of heat shock proteins in atherosclerosis. Nat. Rev. Cardiol. 11, 516–529 (2014). Article CAS PubMed Google Scholar Kearns, A. C. et al. Caspase-1 activation is related with HIV-associated atherosclerosis in an HIV transgenic mouse model and HIV patient cohort. Arterioscler. ...