Protein is a macronutrient that is essential to the human body. Proteins can be consumed or produced by the endoplasmic reticulum within one's body. There are three types of protein - fibrous, globular, and membrane.Answer and Explanation: ...
Unfolded protein responseStressors elicit a neuroendocrine response leading to increased levels of glucocorticoids, allowing the organism to adapt to environmental changes and maintain homeostasis. Glucocorticoids have a broad effect in the body, modifying the activity of the immune system, metabolism, and...
HMGA protein overexpression is a constant feature of human malignant neoplasias. It represents a poor prognostic index as their overexpression often correlates with the presence of metastasis and with a reduced survival. HMGA proteins have a crucial role in cell transformation. They show oncogenic acti...
Advanced prostate and bladder cancer are two outstanding unmet medical needs for urological oncologists. The high prevalence of these tumours, lack of effective biomarkers and limited effective treatment options highlight the importance of basic research
Adolescent depression is becoming one of the major public health concerns, because of its increased prevalence and risk of significant functional impairment and suicidality. Clinical depression commonly emerges in adolescence; therefore, the prevention a
These modifications regulate gene transcription, cellular responses, protein translation, protein degradation, and other critical biological processes. O-GlcNAcylation impacts cell signal transduction and plays a crucial regulatory role in normal growth and development, as well as in the pathogenesis of ...
Therefore, it is crucial to maintain a balanced protein quality in order to minimize cellular dysfunction and death in this population and thereby prevent HF [2]. Protein quality control (PQC) systems are thought to be potential therapeutic targets of HF that can alleviate the damage to CMs, ...
including DGAT2, RAB18, and perilipin (PLIN), are located on LD surfaces, regulating their homeostasis and interactions [9,10]. For instance, DGAT2 catalyzes triacylglycerol generation, whereas proteins of the perilipin family participate in the metabolism of the RAB18 protein and LDs. [11,12,...
A multiprotein cytosolic complex containing members of the NOD-like receptor (NLR) family (such as NLRP3) that integrates signals from several pattern recognition receptors and results in the maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18. Trained immunity The reprogram...
Large (micrometre-sized) extracellular vesicles derived from the plasma membrane of tumour cells. Quorum sensing A process of cell–cell communication by which bacteria share information about cell density and modify their gene expression accordingly. Membrane attack complexes Multiprotein pore-forming comp...