Furthermore, Th17 cells can boost the development of ocular diseases like dry eye disease by directly enhancing the proliferation, differentiation, and plasma cell production of B cells [107]. Th17 cells secrete a range of cytokines, notably IL-17A and interleukin-17F (IL-17F), IL-22, and ...
Microvesicles (MVs) are submicron membrane vesicles between 100 and 1000 nm that shed from the cell surface of both healthy and damaged cells15. By contrast, exosomes are smaller in diameter (between 40 and 100 nm) and are released during facultative or exocytosis16. The shedding of membrane ...
following cell death by ferroptosis, is examined, as these molecules further influence the differentiation and function of immune cells, thereby affecting the occurrence and progression of autoimmune diseases. More
Recent investigations [12] have introduced a newly identified mode of cell death termed ferroptosis, which plays a role in chronic inflammation and organ damage in autoimmune diseases. With a growing body of evidence supporting the involvement of ferroptosis in autoimmune diseases, it is apparent that...
Finally, we generalized the role of CLDN5 in respiratory diseases, intestinal diseases, cardiac diseases, and diabetic ocular complications. This review will provide a theoretical basis for the treatment of tumors and non-CNS diseases targeting CLDN5. 2. Structure The CLDN5 gene is located at 22...
The analysis of inflammation-related proteins in a cargo of exosomes derived from the serum of uveal melanoma patients reveals potential biomarkers of disease progression Cancers, 13 (2021) Google Scholar [98] J. Meldolesi Exosomes and ectosomes in intercellular communication Curr. Biol., 28 (2018...
Myocardial infarction, commonly known as a heart attack, is a serious condition caused by the abrupt stoppage of blood flow to a part of the heart, leading to tissue damage. A significant aspect of this condition is reperfusion injury, which occurs when
They also found that the underly- ing molecular mechanism involves the HANR-mediated sponging of miR‐296 in hepatocellular carcinoma cells, reducing the release of miR‐296 from the cells in the form of exosomes. Consequently, the LECs are able to internalize less exosomal miR‐296, causing ...
In addition, some studies have shown that miRNA can also play a regulatory role in the tumor microenvironment via being carried and secreted by exosomes. For example, Roccaro et al. [30] found miRNAs expression profiles in exosomes secreted by stromal cells derived from MM bone marrow were obv...
(not shown).18However, density gradient centrifugation of blood from both patients with diseases and healthy donors may lead to the detection of heterogeneous populations of “low-density” neutrophils (LDNs) within PBMCs under selected physiological conditions or in response to G-CSF stimulation. ...