Myocardial infarction, commonly known as a heart attack, is a serious condition caused by the abrupt stoppage of blood flow to a part of the heart, leading to tissue damage. A significant aspect of this condition is reperfusion injury, which occurs when
min of reperfusion, circulating T cells (predominantly CD8+ T cells) were reduced, a phenomenon that may be due to cell recruitment to ischemic cardiac tissue, which was most evident in patients with microvascular obstruction on cardiac MI/R injury [26]. CD8+ T cells can amplify inflammati...
Microvesicles (MVs) are submicron membrane vesicles between 100 and 1000 nm that shed from the cell surface of both healthy and damaged cells15. By contrast, exosomes are smaller in diameter (between 40 and 100 nm) and are released during facultative or exocytosis16. The shedding of membrane ...
diabetic retinopathysustained releaseocular drug deliverydesolvation methodMembrane bound vesicles, including microvesicles and exosomes, are secreted by both normal... SS Kanwar,CJ Dunlay,DM Simeone,... - 《Lab on A Chip》 被引量: 135发表: 2014年 DOWN-REGULATION OF MIR-126 IN HUMAN RETINAL PERI...
Finally, we generalized the role of CLDN5 in respiratory diseases, intestinal diseases, cardiac diseases, and diabetic ocular complications. This review will provide a theoretical basis for the treatment of tumors and non-CNS diseases targeting CLDN5. 2. Structure The CLDN5 gene is located at 22...
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with immune cells being a crucial component of the body’s immune system. This review provides an overview...
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with immune cells being a crucial component of the body’s immune system. This review provides an overview...
In autoimmune diseases, their activation and function may differ. While mo-DCs can be detected mainly in blood and tissues under physiological conditions, they are most frequently produced during inflammation and have a high degree of plasticity and variety in their roles [44]. These functions are...
Other channel-independent functions of connexins involve their roles in mitochondria and exosomes. This review summarizes the latest advances in the channel-dependent and independent roles of connexins in fibrosis, the EMT, and wound healing, with a particular focus on eye diseases, emphasizing their...
SALL4 bound to the miR-146a-5p promoter and positively regulated its expression in HCC exosomes. The miR-146a-5p from exosomes increased the number of M2-polarized tumor-associated macrophages that support tumor progression [178]. Altogether, the evidence points to SALL4 as a potential candidate...