Molecular and cellular biology has moved towards complete and accurate knowledge of how molecules behave in space and time. Protein is considered as the primary group of molecules responsible for mediating most physiological processes. Changes in the levels of proteins may lead to the altered function...
Ribosomes, which are important sites for the synthesis of proteins related to expression and transmission of genetic information in humans, have a complex structure and diverse functions. They consist of a variety of ribosomal proteins (RPs), ribosomal RNAs (rRNAs) and small nucleolar RNAs. Owing...
Oncogenic functions of p48 EBP1 and tumor suppressor p42 Ebp1 in human cancers Fig. 2: Protein structure and modifications of EBP1 isoproteins. The two EBP1 isoproteins, p48 (394 a.a, 48 kDa) and p42 (340 a.a, 42 kDa), undergo multiple post-translational modifications: Cyclin-...
Three categories of proteins have been characterized that enable the trans-leaflet movement of lipids: flippases that transfer lipids to the cytosolic leaflet from the PM extracellular or organellar luminal leaflet, floppases that transfer in the opposite direction (out of the cytosolic facing leaflet...
Unstructured sequences have important roles in the functions of a protein:A.Being able to flex and bend, they can wrap around one or more target proteins like a scarf, binding with both high specificity and low affinity.B.By forming flexible tethers betw
In summary, Rho family G proteins are appearing to be regulated by a complex set of RhoGAPs integrating numerous additional domains and functions. Specific combinations of Rhos and GAPs/GEFs might be involved in controlling distinct cellular processes beyond the classical roles of RhoA, Cdc42, and...
Lipid droplets (LDs), which are active organelles, derive from the monolayer membrane of the endoplasmic reticulum and encapsulate neutral lipids internally. LD-associated proteins like RAB, those in the PLIN family, and those in the CIDE family particip
O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a common and important post-translational modification (PTM) linking O-linked β-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues in proteins. Extensive research indicates its impact
functions. Recent approaches in protein biochemistry and systems biology have revealed that Gab proteins are subject to complex regulation by feed-forward and feedback phosphorylation events as well as protein-protein interactions. Thus, Gab/DOS docking proteins are at the centre of entire signalling ...
There have been recent insights from structural studies of Argonaute proteins, including human Argonautes. Mechanisms of small RNA loading and sorting into distinct Argonaute proteins are emerging. Distinct members of the AGO clade have different functions, and there are different repertoires of AGO prot...