All proteins end with a carboxyl terminus that has unique biophysical properties and is often disordered. Although there are examples of important C-termini functions, a more global role for the C-terminus is not yet established. In this review, we summarize research on C-termini, a unique ...
Key roles of Arf small G proteins and biosynthetic trafficking for animal developmenttraffickingdevelopmenttranscriptionbiosynthesisproteinsAlthough biosynthetic trafficking can function constitutively, it also functions specifically for certain developmental processes. These processes require either a large increase ...
It is difficult to overstate the importance of proteins to life as we know it, according to the researchers. Enzymes are proteins that enable chemical reactions in cells; antibodies are proteins that bind to foreign invaders in the body. The list goes on to include thousands of critical functi...
of NFAT proteins can be explained by their complex mechanism of regulation and their ability to integrate calcium signalling with other signalling pathways. This Review focuses on the recent advances in our understanding of the regulation, mechanism of action and functions of NFAT proteins in T ...
Such results suggest that differ- ences in the biochemical roles of DXS proteins seem to be related with variable functions in plant development and growth. In this work, we report the identification and molecular characterization of the tomato white lethal seedling-2297 (wls-2297) mutant, which...
Comprehensive protein-protein interaction network analysis can help reveal protein functions in a system-wide manner. A reliable knowledgebase of interacti... MC Chen - Dissertations & Theses - Gradworks 被引量: 0发表: 2014年 Structural domain-domain interactions: assessment and comparison with protei...
Cellular functions of 14-3-3|[zeta]| in apoptosis and cell adhesion emphasize its oncogenic character 14-3-3 proteins are relevant to cancer biology as they are key regulators of major cellular processes such as proliferation, differentiation, senescence an... M Niemantsverdriet,K Wagner,M Viss...
β-Arrestin-1 and -2 are intracellular proteins that are able to inhibit signaling via G protein-coupled receptors (GPCRs). However, both proteins can also modulate cellular functions in a G protein-independent fashion. During the past few years, studies with mutant mice selectivity lacking β-...
Intracellular membrane proteins such as alpha syntrophin [10] and extracellular matrix proteins such as agrin may form part of the AQP4 anchoring mechanism [11], but further research is required to define the molecular anchor. In this review we discuss the functions of AQPs in tumor cells and...
Cardiac tissue is composed of various cell types, and the cooperation of distinct cell types contributes to the crucial functions of the heart. Previous pioneering research has revealed that the heart comprises 70% noncardiomyocytes and 30% cardiomyocytes, which can be grouped into atrial and ventric...