G protein-coupled receptors (GPCRs) selectively activate at least one of the four families of heterotrimeric G proteins, but the mechanism of coupling selectivity remains unclear. Structural studies emphasize structural complementarity of GPCRs and nucle
Accession codes: Atomic coordinates and structure factors have been deposited in the Protein Data Bank under accession code 3ZJZ. How to cite this article: Bagnéris, C. et al. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. Nat. Commun. 4:2465 do...
We performed a virtual screening of protein data bank (PDB) using docking simulations with the integrin headpiece as a target. We showed that several growth factors (e.g., FGF1 and IGF1) induce a integrin-growth factor-cognate receptor ternary complex on the surface. Growth ...
protein dynamic Introduction Allostery (from the Greek allos stereos“other solid”) is the regulation of protein function through the binding of an effector molecule at a site remote from the active site and can switch proteins between active and inactive states (1). Allostery is a fundamental ...
Bacteria of the Xanthomonas genus are mainly phytopathogens of a large variety of crops of economic importance worldwide. Xanthomonas spp. rely on an arsenal of protein effectors, toxins and adhesins to adapt to the environment, compete with other microorganisms and colonize plant hosts, often caus...
Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data. Am J Med Genet B Neuropsychiatr Genet. 2018;177(7):641-657. PubMedGoogle ScholarCrossref 13. Pouget JG, Han B, Wu Y, et al; Schizophrenia Working Group of the ...
After repeat masking, protein-coding genes on novel sequences were predicted and refined to remove redundant and incomplete genes. To identify the presence or absence of each gene in each accession, the ‘map-to-pan’ strategy was used (Sun et al., 2017). Reads from each accession were ...
Schematic diagram showing the viral particle structure of SARS-CoV-2(A), and the genome organization of SARS-CoV-2 genes(B). The structural components of the spike (S) protein; S2 contains signal peptide (SP), N-terminal domain (NTD), and receptor binding domain (RBD). The S1 contains...
The cannabinoid receptor 1 (CB1) is a class A G-protein coupled receptor (GPCR) that can exert various effects on the human body through the endocannabinoid system. Understanding CB1 activation has many benefits for the medical use of cannabinoids. A pre
Atomic coordinates and structure factors for the StFliD401–467-StFliT1–94 complex have been deposited in the Protein Data Bank (PDB ID code 5GNA). Size exclusion chromatography with multi-angle light scattering (SEC-MALS) SEC-MALS experiments were performed using an FPLC system (GE Health...