11,12,13,14 Protein properties influencing the adsorption are protein size, charge, hydrophobicity, and concentration; solution properties important for adsorption inside the human body are, e.g., ionic strength, pH, shear rates, and agitation.15 Adsorption as the first step of metal–protein ...
Proteins comprise 22 ‘building blocks’ called amino acids. However, the body cannot produce 9 out of the 22 amino acids. Hence, it has to reach out to the body in the form of a regulated diet, through food intake. TheDRI(Dietary Reference Intake) suggests that 0.75 grams of protein pe...
et al. Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster. Aging cell 11, 634–643 (2012). Although proteasome activity declines in somatic tissues during the ageing process, maturating oocytes and gonads maintain their high activity compared...
The incidence of endogenous infectious inflammatory diseases has dramatically increased in the population during the past 50 years. The causative agents of these diseases are representatives of the body's commensal microflora, to which oral tolerance (OT) of the host develops. Disorders of this tolera...
Melanocortins Melanocortin receptor Neuropeptide ACTH (adrenocorticotropic hormone) AgRP (agouti-related protein) POMC (proopiomelanocortin) Energy homeostasis Obesity Sexual function 1. Introduction Melanocortins were discovered as bioactive substances of the pituitary that modulate skin color in frogs (Smith,...
Foreign body giant cellsForeign body giant cells (FBGCs) are a hallmark of the foreign body reaction caused by biomaterial implantation and are thought to contribute to biomaterial degradation and the duration of the response. Osteopontin (OPN) is a secreted, acidic matricellular protein with ...
S100A4 is the first multifunctional S100 protein identified in metastatic cancer cells, distributed in the cytoplasm, nucleus, and extracellular regions [16]. It not only promotes cancer metastasis but also various other human inflammation-related diseases such as RA [17]. The expression of S100A4...
In particular, the protein content of EVs depends on the cell type from which they are secreted. Biogenesis of extracellular vesicle (EV) subtypes such as exosomes, MV, syncytial nuclear aggregates and apoptotic bodies. EVs are intraluminal vesicles which are released when a multivesicular body ...
protein complexes called inflammasomes that have been increasingly shown to play a vital role in the immune system. The history of inflammasome-related research dates back to 1985, when Hanazawa and colleagues first showed that exposure to Lipopolysaccharide (LPS) induces interleukin-1 (IL-1) ...
There is an increasing amount of evidence that biomolecular condensates are linked to neurodegenerative diseases associated with protein aggregation, such as Alzheimer’s disease and amyotrophic lateral sclerosis, although the mechanisms underlying this