(2003) Role of the promoter in maintaining transcriptionally active chromatin structure and DNA methylation patterns in vivo. Mol. Cell. Biol. 23, 4150-4161.Kang,S.H., Kiefer,C.M., and Yang,T.P. (2003). Role of the promoter in maintaining transcriptionally active chromatin structure and ...
We found two key cis-regulatory elements in the immediate vicinity upstream of the gene. One element acts as an essential promoter, whereas the other acts as a tissue-dependent enhancer/repressor. This latter regulatory element contains a runt related-transcription factor (RUNX) recognition motif ...
Eosinophil-derived neurotoxin (EDN) found in the granules of human eosinophils is a cationic ribonuclease toxin. Expression of the EDN gene (RNS2) in eosinophils is dependent on proximal promoter sequences in combination with an enhancer located in the first intron. We further define here the act...
The promoter region of the human Podxl gene has been cloned and its structure and function were analyzed. The primary DNA sequence is rich in G+C and is devoid of TATA or CAAT boxes. The sequence contains recognition sites for several putative transcription factors; however, the basic promoter...
Open complex formation during transcription initiation at the Escherichia coli galP1 promoter: The role of the RNA polymerase subunit at promoters lac... D. (1999). Open complex formation during transcription initiation at the Escherichia coli galP1 promoter: the role of the RNA polymerase a subun...
SNAIL binds to E-box motifs in promoter regions and recruits chromatin remodelers to repress or activate gene expression. To identify proteins associated with SNAIL, we used co-immunoprecipitation of SNAIL-bound proteins followed by mass spectrometry. A large number of splicing proteins associated with...
www.nature.com/scientificreports OPEN Critical Role of Transcription Factor PU.1 in the Function of the OX40L/ TNFSF4 Promoter in Dendritic Cells received: 24 March 2016 accepted: 19 September 2016 Published: 06 October 2016 Takuya Yashiro1,2,3, Mutsuko Hara2, Hideoki Ogawa2, Ko ...
Regulation of AP-1 activity involves G-proteins, adapter proteins, MAP kinases, and other components of cell regulatory systems. Genes responsive to AP-1 play an important role in regulating cell proliferation, morphogenesis, apoptosis, and differentiation. 关键词: AP 1 transcription factors gene ...
MED1 is known to play an essential role in ER-α-mediated gene transcription20,21. We show that estrogen (E2)-activated ER-α targets MED1 to recruit Mediator complex to the promoter of miR-191/425 cluster inducing their transcription. Both miR-191 and MED1 promote breast cancer cell ...
Therefore, we used HCC1806 cells as a model system to explore the role of EGR1 in miR-20b transcription. siRNA knockdown of EGR1 attenuated miR-20b expression. Luciferase assays showed that whereas EGR1 stimulated luciferase activity driven by the wild-type miR-20b promoter, this induction was...