The final phase 4 continues to the next rapid depolarization. The action potential is the result of a concerted action of inward (depolarizing) and outward (hyperpolar-izing) ionic currents. The outward component is carried by K + ions through potassium-permeable transmembrane proteins, the ...
The role of potassium in the body is to control the muscles, nervous system and kidney activity, in order to maintain normal heart beat, also need the right amount of potassium. In calcium binding, it has a lower blood pressure. 翻译结果2复制译文编辑译文朗读译文返回顶部 ...
Other signalling pathways may show cross-talk with this primary mechanism, but we suggest that a role for mitochondrial potassium channels is unlikely. The evidence for their activity in isolated mitochondria and cardiac myocytes is reviewed and the lack of specificity of the pharmacological agents ...
The effect of increased potassium conductance on the genesis of R-wave amplitude increase during acute myocardial ischemia has been studied in the isolated perfused rat heart by simultaneously recording the R-wave amplitude of epicardial electrograms (VEE), heart rate (HR), coronary flow rate (CFR...
Calcium/calmodulin-dependent protein kinase II and potassium channel subunit Eag similarly affect plasticity in Drosophila Proc. Natl. Acad. Sci. U. S. A., 91 (1994), pp. 10044-10048, 10.1073/pnas.91.21.10044 Google Scholar Hamdan et al., 2009 F.F. Hamdan, J. Gauthier, D. Spiegelman,...
Sugar-sweetened beverages (SSBs) are a major source of added sugars in the diet. A robust body of evidence has linked habitual intake of SSBs with weight gain and a higher risk (compared with infrequent SSB consumption) of type 2 diabetes mellitus, cardi
Several cytokines including TNF-α, TGF-β, and different interleukins such as IL-1 IL-4, IL-6, IL-8, and IL-18 are involved in the development of various inflammatory cardiac pathologies, namely ischemic heart disease, myocardial infarction, heart failure, and cardiomyopathies. In ischemia...
The transmembrane organization of a potassium channel from Streptomyces lividans has been studied using site-directed spin labeling techniques and electron... E Perozo,DM Cortes,LG Cuello - 《Nature Structural Biology》 被引量: 537发表: 1998年 Mechanism of odorant adaptation in the olfactory receptor...
Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work has identified that TXNIP has a far wider range of additional roles: from re
Objective: Proinflammatory cytokines are known to play roles in ischemia-reperfusion injury of the heart, kidney, small bowel, skin, and liver. Little is known about their roles in ischemia-reperfusion injury of the lung. This study was undertaken to define the role of 2 proinflammatory cytokines...