These results also imply that, similar to the immunosuppressant effect produced by the blockade of calcineurin activation by CsA, PARP-1 inhibition may also be beneficial in the modulation of immune functions.; In a second project, I investigated the role of PARP-1 in the onset of obesity and...
Cancer is a global health problem and one of the leading causes of mortality. Immune checkpoint inhibitors have revolutionized the field of oncology, emerging as a powerful treatment strategy. A key pathway that has garnered considerable attention is programmed cell death-1 (PD-1)/programmed cell ...
PARP1 Association with DNA Replication Forks PARP1 Association with DNA Hairpins/Cruciforms PARP1 Association with R-loops PARP1 Association with DNA G-quadruplexes (G4 DNA) Concluding Remarks CRediT authorship contribution statement Declaration of Competing Interest Acknowledgements ReferencesShow full out...
Cancer is a global health problem and one of the leading causes of mortality. Immune checkpoint inhibitors have revolutionized the field of oncology, emerging as a powerful treatment strategy. A key pathway that has garnered considerable attention is programmed cell death-1 (PD-1)/programmed cell ...
TP53 is mutated in about 90% of individuals with the most frequent subtype, HGSOC. The development of a breakthrough therapy targeting poly ADP ribose polymerase (PARP) via inhibitors was prompted by advances in next-generation sequencing, which revealed that mutations in DNA repair pathways, ...
The advent of immune checkpoint inhibition (ICI) using antibodies against PD1 and its ligand PDL1 has prompted substantial efforts to develop complementary drugs. Although many of these are antibodies directed against additional checkpoint proteins, there is an increasing interest in small-molecule immuno...
of PARPi response in patients who are PARPi naïve. However, there are indeed some limitations in NGS analyses. A subset of patients can benefit from PARPi, despite the failed detection of the predictive biomarkers such asBRCA1/2mutations or HRR deficiency. Moreover, in the recurrent ...
Thyroid cancer (TC) represents one of the most prevalent endocrine malignancies, with a rising incidence worldwide. Epigenetic alterations, which modify gene expression without altering the underlying DNA sequence, have garnered significant attention in
Poly(ADP-ribose) polymerase-1 (PARP1) is a protein that plays key roles in cellular regulation, namely in DNA damage repair and cell survival. The inhibition of PARP1 promotes cellular death in cells with homologous recombination deficiency, and therefore, the interest in PARP protein has been...
Gene expression is one of the most critical cellular processes. It is controlled by complex mechanisms at the genomic, epigenomic, transcriptomic, and proteomic levels. Any aberration in these mechanisms can lead to dysregulated gene expression. One rece