In this perspective, we hypothesize that the localization of mTORC1 and lysosome could be interconnected in a way that manifests regulation of autophagy that is already under progression at the time of mTORC1 activation. This provides a new possibility for autophagy regulation whose complete ...
According to the prevailing model, AMPK phosphorylates and activates ULK1 (UNC-51 like kinase 1) to induce autophagy8,9. Mechanistic target of rapamycin complex 1 (mTORC1), the key negative regulator of autophagy, prevents the function of AMPK by disrupting the interaction between AMPK and ULK1...
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain cellular homeostasis. The mTOR signaling cascade consists of two distinct multi-subunit complexes named mTOR complex...
Induction of mTORC1 in senescent cells can lead to the development of the SASP, and mTORC1 inhibitors appear to decrease the inflammatory response caused by senescent cells and can also inhibit the SASP through different mechanisms [73, 74]. Furthermore, the m-TOR signalling pathway can control...
In recent years, studies have paid more attention to nutritional sensing and its pathophysiological significance. As the vital role in the cell growth, amino acid sensing has received the most attention. mTORC1 is the key sensing signaling in amino acid sensing. The precise sensing of amino acid...
latent infection [111]. Interestingly, Pringle et al. found that mTORC1 is dispensable for KSHV’s protein synthesis, genome replication, and the release of infectious progeny virions, which means that the virus may have subverted the controlling role of mTOR to autophagy at this stage [112]....
latent infection [111]. Interestingly, Pringle et al. found that mTORC1 is dispensable for KSHV’s protein synthesis, genome replication, and the release of infectious progeny virions, which means that the virus may have subverted the controlling role of mTOR to autophagy at this stage [112]....
TheRoleofAutophagyinCancer:TherapeuticImplications ZhinengJ.Yang,ChengE.Chee,ShengbingHuang,andFrankA.Sinicrope Abstract Autophagyisahomeostatic,catabolicdegradationprocesswherebycellularproteinsandorganellesare engulfedbyautophagosomes,digestedinlysosomes,andrecycledtosustaincellularmetabolism.Autophagy ...
regulate transcription. For example, if nutrient is in abundance, TFEB is phosphorylated by mTORC1, which facilitates 14-3-3-dependent retention of TFEB in cytoplasm and prevents transcription function of TFEB [9]. On the contrary, in the context of starvation or mTOR inhibitor treatment, ...
Concerning mTOR pathway, to suppress the autophagy we activated mTOR, recording a significant increase in splice correction activity, in agreement with the fundamental role of mTOR in autophagy inhibition. Additionally, several nanoparticles have also been shown to downregulate this pathway12,51,52,53...