1、研究表明，mTORC1 通过磷酸化使形成的自噬调节复合物 (由 ULK1 和其互作蛋白 Atg13、FIP200、Atg101 等形成) 失活，从而影响自噬小体的生物发生。在营养丰富的条件下，mTORC1 通过介导 ULK1 (Ser637 和 Ser757) 和 Atg13 (Ser258) 特定位点磷酸化，抑制 ULK1 复合物的自噬促进激酶 (Autophagy-promoting ...
Akt为蛋白激酶B,TSC1为结节性硬化症复合体1,TSC2为结节性硬化症复合体2,mTOR为哺乳动物雷帕霉素靶蛋白,NF-κB为核因子-κB,Nrf2为核因子E2相关因子2,GSK3β为糖原合酶激酶3β,FasL为人凋亡相关因子配体,CytC
7. Wang H, et al. The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases. Cells. 2019; 8(12): 1597. 8. Kim YC, et al. mTOR: a pharmacologic target for autophagy regulation. J Clin Invest. 2015; 125(1): 25-32. 9. Akpedje S. Dossou, et al. The Emerging Roles of ...
autophagy.mTOR can be regulated by every upstream factor,as well as modulate the formation of downstream complex Atg1/ULK and eventually induce autophagy.Understanding of mTOR signaling pathway and its function on autophagic complexes will help to analyze and treat various tumors from the molecular ...
15. Efeyan, A. et al. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.Nature 493, 679-683, doi:10.1038/nature11745 (2013).16. Li, M. et al. Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1.Cell Res, doi:...
Salvia miltiorrhiza on the mTOR pathway and autophagy, and prospects for their application in the treatment of MIRI. Keywords: myocardial ischemia-reperfusion injury; traditional Chinese medicine; mTOR pathway; autophagy 一、引言 近年来,心肌缺血再灌注损伤(Myocardial ischemia-reperfusion ...
Moreover, sulforaphane treatment significantly attenuated rotenone-inhibited mTOR-mediated p70S6K and 4E-BP1 signalling pathway, as well as neuronal apoptosis. In addition, sulforaphane rescued rotenone-inhibited autophagy, as detected by LC3-II. Collectively, these findings demonstrated that sulforaphane ...
Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway Xiangjin Zheng, Wan Li, Huanli Xu, Jinyi Liu, Liwen Ren, Yihui Yang, Sha Li, Jinhua Wang*, Tengfei Ji*, Guanhua Du* ...
[4] Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J,Aguirre-Ghiso JA. Perk integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol Cell Biol. 2011, 31(17): 3616-3629 [5] Fischer RS, Myers KA, ...
R7:Autophagy, apoptosis and G2/M phase arrest aremediated by the activation of ROS/JNK signaling andinhibition of the Akt/mTOR signaling pathway 为了确定雷公藤红素诱导的自噬、凋亡和G2/M期阻滞是否与ROS/JNK信号通路和Akt/mTOR信号通路有关,作者进一步研究了NAC、SP、MK和Ra。