Queen Mary Univ London Womens Hlth Res Unit London EnglandAnticancer Research: International Journal of Cancer Research and TreatmentMichail,Sideris,Elif Iliria,etc.The Role of KRAS in Endometrial Cancer: A Mini-Review.[J].2019,39(2).
KRAS mutation: from undruggable to druggable in cancer Article Open access 15 November 2021 Data availability The data that support the findings of this study are available at cBioportal and https://genie.cbioportal.org/. References Santarpia, L., Lippman, S. M. & El-Naggar, A. K. Targ...
在发现索托菲尼之前,这些蛋白质被认为是“undruggable”,索托菲尼是KRAS-G12C突变蛋白质的直接抑制剂,在非小细胞肺癌患者中具有很好的活性,尽管对这种化合物的获得性抗性是常见的。KRAS-G12C的另一种选择性抑制剂阿达格列西布也显示出对KRAS-G12C阳性非小细胞肺癌和其他实体肿瘤患者的令人鼓舞的临床活性。其他针对RA...
Role of KRAS Mutations in Patients with Metastatic Colorectal Cancer Who Receive Regorafenib Plus FOLFIRI as a Salvage Therapydoi:10.1016/j.ejso.2018.10.213Y.C. ChenC. Tsung-KunT. Hsiang-LinS. Wei-ChihW. Jaw-YuanElsevier BVEuropean Journal of Surgical Oncology...
Cancer- related pathways in ferroptosis RAS RAS家族(HRAS、NRAS和KRAS)的癌基因是所有人类癌症中最常见的突变。在发现索托菲尼之前,这些蛋白质被认为是“undruggable”,索托菲尼是KRAS-G12C突变蛋白质的直接抑制剂,在非小细胞肺癌患者中具有很好的活性,尽管对这种化合物的获得性抗性是常见的。KRAS-G12C的另一种选...
Collagen is the major component of the tumor microenvironment and participates in cancer fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes, transcription factors, signaling pathways and receptors; furthermore, collagen can influence tumor cell behavior through integrins,...
regulatory T cells and myeloid-derived suppressor cells (MDSC), predominate in the early response and persist through invasive cancer (14). Phenotype changes of the stellate cells occur earlier than noticeable changes in other pancreatic components (15). Thus, even low levels of KRAS activity gener...
此外,KRAS- G12D可在铁死亡期间由胰腺癌细胞在外泌体中释放,并可被巨噬细胞吸收。这种摄取是由AGER介导的,最终导致巨噬细胞极化为M2表型并刺激肿瘤生长。除了这些蛋白质之外,某些非蛋白质阻尼(如ATP、宿主DNA和脂质介质)可能会产生一个复杂的网络,在铁死亡期间调节抗肿瘤免疫。不同于SLc7a11清除介导的胰腺肿瘤抑制...
et al. Platelets subvert T cell immunity against cancer via GARP-TGFβ axis. Sci. Immunol. 2, eaai7911 (2017). Article PubMed PubMed Central Google Scholar Casagrande, N. et al. In ovarian cancer multicellular spheroids, platelet releasate promotes growth, expansion of ALDH+ and CD133+ ...
in TNBC, indeed a c-Mychigh/TXNIPlowsignature correlates with poor OS specifically in this subclass of breast cancer [36]. When compared with iAP mice (mice harbouring conditional null alleles ofApcandTrp53), iKAP mice (engineered with a doxycycline-inducible oncogenicKrasallele and conditional ...