Our results support the emerging view on the role of electrostatics in general and that of hydrogen bonds in particular which is that hydrogen bonds do not drive protein-DNA complex formation by virtue of the unfavourable cost of the electrostatics of desolvation. They however, act to stabilize ...
Dizdaroglu M, Olinski R, Doroshow JH, Akman SA: Modification of DNA bases in chromatin of intact target human-cells by activated human polymorphonuclear leukocytes. Cancer Res 53: 1269–1272, 1993 Murata M, Imada M, Inoue S, Kawanishi S: Metal-mediated DNA damage induced by diabetogenic all...
The recognition of specific DNA sequences by proteins is thought to depend on two types of mechanism: one that involves the formation of hydrogen bonds with specific bases, primarily in the major groove, and one involving sequence-dependent deformations of the DNA helix. By comprehensively analysing...
The physical chemistry of hydrogen bonds Intermolecular interactions are complex and often – even in leading textbooks – their description is heavily simplified and sometimes even incorrect (Truhlar2019). Hydrogen bonding is a simple name for a complex situation, even in the case of two isolated ...
Such a difference is strictly related to the changes in the hydrogen bond network between the protein, the DNA and the drug in the two systems, indicating a direct role of the protein in determining the specificity of the cleavage site sequence stabilized by the CPT. ...
Proton transfer across hydrogen bonds in DNA can produce non-canonical nucleobase dimers and is a possible source of single-point mutations when these forms mismatch under replication. Previous computational studies have revealed this process to be energetically feasible for the guanine-cytosine (GC) ba...
C-H.O hydrogen bonds in minor groove of A-tracts in DNA double helices. Analysis of available B-DNA type oligomeric crystal structures as well as protein-bound DNA fragments (solved using data with resolution <2.6 A) indicates ... A Ghosh,M Bansal - 《Journal of Molecular Biology》 被引...
Nucleotides are sometimes referred to as base pairs, as they form complementary base pairing in the DNA structure via hydrogen bonds; adenine forms double bonds with thymine, while cytosine forms triple bonds with guanine. The human genetic code is composed of 6.4 billion base pairs. DNA ...
RNases are a broad class of enzymes that are specific for cleaving RNA molecules. RNases are commonly used in molecular biology laboratories during the purification of DNA and proteins. Different sub-classes of RNase are present, such as RNase A, RNase H, RNase P, RNase L, RNase III, ...
DNA: Chemical Structure of Nucleic Acids & Phosphodiester Bonds from Chapter 9 / Lesson 1 255K Nucleic acids are large biomolecules used to store, transfer and convey genetic information in cells. Explore the structure of nucleotides and what polynucleotide and phosphodiester bonds do. Related...