Understanding the role of hydrogen bonds in destruction of DNA by screening interactions of Flutamide anticancer drug with nucleotides bases: DFT perspective, MD simulation and free energy calculationdoi:10.1007/s10450-019-00179-2Maedeh KamelHeidar Raissi...
the hydrogen-bonding liquidpar excellence. This means that H-bonds within or between biomolecules always have to compete with H-bonds to water, and in this competition the relatively high mobility, both translational and rotational, of the water molecules with the unparalleled capacity of...
Proton transfer across hydrogen bonds in DNA can produce non-canonical nucleobase dimers and is a possible source of single-point mutations when these forms mismatch under replication. Previous computational studies have revealed this process to be energetically feasible for the guanine-cytosine (GC) ba...
The recognition of specific DNA sequences by proteins is thought to depend on two types of mechanism: one that involves the formation of hydrogen bonds with specific bases, primarily in the major groove, and one involving sequence-dependent deformations of the DNA helix. By comprehensively analysing...
Stohs SJ, Bagchi D: Oxidative mechanisms in the toxicity of metal-ions. Free Rad Biol Med 18: 321–336, 1995 Balasubramanian B, Pogozelski WK, Tullius TD: DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone. Pr...
The intermolecular hydrogen bond between hydrogen donor and acceptor molecules exemplify this type of interaction, which plays a vital role in many molecular and supramolecular systems such as polymers, proteins, DNA, and self-assembled molecular architectures [2], [3], [4], [5], [6], [7],...
1. DNA is made of complementary strands and repairs can be made when one side is damaged 2. The nucleotides are protected inside the sugar-phosphate backbone and secured by hydrogen bonds. 3. DNA structure (nucleosomes etc) provide a tight structure which restricts access. Point ...
Although DNA polymerase fidelity has been mainly ascribed to Watson-Crick hydrogen bonds, two nonpolar isosteres for thymine (T) and adenine (A)—difluorotoluene (F) and benzimidazole (Z)—effectively mimic their natural counterparts in polymerization experiments with pol I (KF exo) [JC Morales ...
protein-DNA recognition DNA structure binding affinity and stability Introduction The tumor-suppressor protein p53 acts as a transcription factor converting intracellular stress signals into the expression of numerous genes involved in cell-cycle arrest, cell death, and DNA repair (Beckerman and Prives, ...
RNases are a broad class of enzymes that are specific for cleaving RNA molecules. RNases are commonly used in molecular biology laboratories during the purification of DNA and proteins. Different sub-classes of RNase are present, such as RNase A, RNase H, RNase P, RNase L, RNase III, ...