Gut microbiomeImmune checkpoint therapyImmune regulationColorectal cancer (CRC) is one of the most frequent gastrointestinal malignant tumors worldwide. Immune checkpoint therapies (ICTs) have been proven to be a reliable treatment for some subtypes of CRC. Gut microbiome is closely involved in ...
1. The human gut microbiome interaction with the immune system in age and disease 2. The gut microbiome and age-related macular degeneration 3. The gut microbiome and retinal artery occlusion 4. The gut microbiome and central serous chorioretinopathy 5. The gut microbiome and inflammatory eye ...
The gut microbiome, i.e., the community of bacteria and other microorganisms living in the human gut, has been implicated both directly and indirectly (mediating the effects of diet) on human health [1,2]. The associations between gut microbiome composition and disease status have been widely ...
Here we conducted a large-scale metagenomic analysis on the gut microbiome of 307 samples collected longitudinally from gout patients and healthy controls. Utilizing both discovery and validation cohorts, we sought to investigate the taxonomic and functional signatures of gut microbiome in gout, its ass...
Given that around 70% of the immune cells are located in the gut, the potential role of the gut microbiota in the etiopathogenesis of JIA has been recently investigated. The aim of this review is to discuss the complexity of the link between gut microbiota and JIA, the different methods ...
The gut microbiome is considered as an organ that contributes to the regulation of host metabolism. Mammals possess an ‘extended genome’ of millions of microbial genomes located in the intestine: the microbiome. To date, there is rapidly booming eviden
Infections are common complications and causes of death during immunochemotherapy in diffuse large B-cell lymphoma (DLBCL). The gut microbiota plays a significant role in bacterial infection, but its relationship and predictive capacity with infectious complications in DLBCL are unknown. Methods We perfo...
multiple databases of the gut microbiome have been built to examine these functions(Table1). These functions are related to the pathological processes of many human diseases, especially the development, progression, and immune evasion of cancer, as well as the modulatory effects of cancer treatments...
In the proposed study, we will directly test the Thrifty Mirobiome Hypothesis by performing detailed genomic and functional assessment of gut microbial communities in intensively phenotyped and genotyped human subjects before and after intentional manipulation of the gut microbiome. To address this ...
Liver transplantation has become the accepted standard of care in the treatment of a child with a failing liver. Advances in the management of critical care and immunosuppression along with the development of innovative operative procedures have improved outcome such that 5-year survival rates of 80...